Article

Projet
Nucléosides et analogues aux propriétés antivirales et/ou antitumorales  
Jean-Luc DECOUT,   
Titre
A new straightforward synthesis of 2’, 3’-didehydro-2’, 3’-dideoxy-2’-(2”- (trimethylsilyl)ethylthio)thymidine, key intermediate for the synthesis of 2’-substituted thionucleosides  
Auteurs
Maralise P. Oliveira, Lucas L. Franco, Maria C. A. Lima, Cláudia M. O. Simões, Suely L. Galdino, Ivan R. Pitta, Jean-Luc Décout, Ricardo J. Alves
Edition
J. Braz. Chem. Soc. 26, 816-821, 2015
Année
2015
Résumé
We describe herein a straightforward and efficient preparation of 2’,3’-dideoxy-2’-(2’’- (trimethylsilyl)ethylthio)thymidine, which allows the preparation of diverse potentially antiviral and/or anticancer nucleosides (disulfides, thiols, sulfides, thiocyanates).