Article

Projet
 
Benjamin BOUCHERLE,   
Titre
NMR evaluation of interactions between substituted-indole and PDZ1 domain of PSD-95  
[Full paper ]
Auteurs
Alexandre Vogrig, Benjamin Boucherle, Hemantkumar Deokar, Isabelle Thomas, Isabelle Ripoche, Lu-Yun Lian, Sylvie Ducki
Edition
Bioorganic & medicinal chemistry letters 06/2011; 21(11):3349-53
Année
2011
Résumé
We synthesized small organic molecules designed as PDZ ligands. These indole-based compounds were evaluated for their interaction with the PDZ1 domain of the post-synaptic density 95 (PSD-95) protein. Three molecules were found to interact with the targeted PDZ protein by NMR. One of them showed chemical shift perturbations closely related to the natural ligands.