Outils de formulation et de vectorisation de substances actives  
Denis WOUESSIDJEWEAnnabelle GEZE,   
Biocompatible Double-Membrane Hydrogels from Cationic Cellulose Nanocrystals and Anionic Alginate as Complexing Drugs Codelivery  
[Full paper ]
Ning Lin, Annabelle Gèze, Denis Wouessidjewe, Jin Huang, and Alain Dufresne
ACS Applied Materials & Interfaces 2016, 8(11), 6880-6889
A biocompatible hydrogel with a double-​membrane structure is developed from cationic cellulose nanocrystals (CNC) and anionic alginate. The architecture of the double-​membrane hydrogel involves an external membrane composed of neat alginate, and an internal composite hydrogel consolidates by electrostatic interactions between cationic CNC and anionic alginate. The thickness of the outer layer can be regulated by the adsorption duration of neat alginate, and the shape of the inner layer can directly det. the morphol. and dimensions of the double-​membrane hydrogel (microsphere, capsule, and film-​like shapes)​. Two drugs are introduced into the different membranes of the hydrogel, which will ensure the complexing drugs codelivery and the varied drugs release behaviors from two membranes (rapid drug release of the outer hydrogel, and prolonged drug release of the inner hydrogel)​. The double-​membrane hydrogel contg. the chem. modified cellulose nanocrystals (CCNC) in the inner membrane hydrogel can provide the sustained drug release ascribed to the "nano-​obstruction effect" and "nanolocking effect" induced by the presence of CCNC components in the hydrogels. Derived from natural polysaccharides (cellulose and alginate)​, the novel double-​membrane structure hydrogel material developed in this study is biocompatible and can realize the complexing drugs release with the first quick release of one drug and the successively slow release of another drug, which is expected to achieve the synergistic release effects or potentially provide the soln. to drug resistance in biomedical application.