Farid OUKACINE  

Projets

• Nouveaux systèmes d'administration. Dans le cadre de ce projet inter-équipe, l'objectif est de mettre au point des systèmes intelligents d'administration de nouveaux médicaments candidats d'une part, et d'autre part de développer des formes pharmaceutiques de médicaments disponibles dans le commerce, de manière plus adaptées aux besoins du patient. Le projet associe les compétences des deux équipes de l'unité, ainsi que celles du CHU Grenoble Alpes.

• Mise au point de dispositifs d'analyse innovants. Ce projet comprend deux volets : d'une part, il s'agit de développer des tests de diagnostic faciles à utiliser, rapides, peu coûteux et/ou portables à l'aide d'aptamères, afin de facilité les soins aux patients ou de détecter les contaminants environnementaux ; d'autre part, l'objectif est d'établir de nouvelles stratégies de signalement pour le développement de dispositifs à haut débit et/ou haute sensibilité.

Publications

• Article • Quantification of ions and organic molecules, in nanoliter samples, in the absence of reference materials [Full paper ]

  L. Lavigne, L. Choisnard, E. Peyrin, F. Oukacine

  Anal. Chem. 2022, 94, 15546−15552

• Article • Aptamer Switches Regulated by Post-Transition/Transition Metal Ions [Full paper ]

  B. Billet, B. Chovelon, E. Fiore, F. Oukacine, M-A Petrillo, P. Faure, C. Ravelet, E. Peyrin

  Angew. Chem. Int. Ed. 2021, 60, 12346–12350

• Article • Inline coupling of electrokinetic preconcentration method to Taylor dispersion analysis for size-based characterization of low-UV-absorbing nanoparticles 

  F. Oukacine, A. Gèze, L. Choisnard, JL. Putaux, JP. Stahl, E. Peyrin

  Anal. Chem. 2018, 90, 2493–2500

• Article • Sequence Requirements of Oligonucleotide Chiral Selectors for the Capillary Electrophoresis Resolution of Low-Affinity DNA Binders 

  L . Tohala, F. Oukacine, C. Ravelet, E. Peyrin

  Electrophoresis, 2017, 38, 1383-1390

• Article • Chiral resolution capabilities of DNA oligonucleotides [Full paper ]

  L. Tohala, F. Oukacine, C. Ravelet, E. Peyrin

  Anal. Chem. 2015, 87, 5491-5495.

• Article • Enantiomeric sensing and separation by nucleic acids [Full paper ]

  F. Oukacine, C. Ravelet, E. Peyrin

  Trends Anal. Chem. 2020, 122, 115733

• Article • Capillary electrophoretic apparatus for the endpoint detection in microtitration methods [Full paper ]

  F. Oukacine, L. Choisnard, A. Gèze, E. Peyrin

  J. Chromatogr. A, 2019

• Article • Capillary electrophoretic focusing of covalently derivatized protein induced by surfactant [Full paper ]

  F. Oukacine, J. P. Quirino, K. Mesbah, M. Taverna

  Electrophoresis 2016, 37, 1151-1154

• Article • Multiple capillary isotachophoresis with repetitive hydrodynamic injections for performance improvement of the electromigration preconcentration [Full paper ]

  T. Mai, F. Oukacine, M. Taverna

  J. Chromatogr. A 2016, 1543, 116-123

• Article • Size-based characterization of nanoparticle mixtures by the inline coupling of Capillary Electrophoresis to Taylor Dispersion Analysis [Full paper ]

  F. Oukacine, A. Morel, I. Desvignes, H. Cottet

  J. Chromatogr. A 2015, 1426, 220-225.

• Article • Physico-chemical characterization of polymeric micelles loaded with platinum derivatives by capillary electrophoresis and related methods [Full paper ]

  F. Oukacine, S. Bernard, I. Bobe, H. Cottet

  J. Control. Release 2014, 196, 139-145.

• Article • An improved capillary electrophoresis method for in vitro monitoring of the challenging early steps of A beta(1-42) peptide oligomerization: Application to anti-Alzheimer's drug discovery [Full paper ]

  D. Brinet, J. Kaffy, F. Oukacine, S. Glumm, S. Ongeri, M. Taverna

  Electrophoresis 2014, 35, 3302-3309.

• Article • Poly(glycidyl methacrylate)/silver nanocomposite microspheres as a radioiodine scavenger: Electrophoretic characterisation of carboxyl- and amine-modified particles [Full paper ]

  H. Mackova, F. Oukacine, Z. Plichta, M. Hruby, J. Kucka, M. Taverna, D. Horak

  J. Colloid Interface Sci. 2014, 421, 146-153.

• Article • Suppression of Apparent Fluid Flow in Capillary Isotachophoresis without Recourse to Capillary Coating [Full paper ]

  F. Oukacine, M. Taverna

  Anal. Chem. 2014, 86, 3317-3322

• Article • On-line capillary electrophoresis derivatization method for high sensitivity analysis of ubiquitin in filtered cerebrospinal fluid [Full paper ]

  K. Mesbah, F. Oukacine, S. Lehnert, M. Otto, M. Taverna

  Electrophoresis 2013, 34, 2733-2739.

• Article • Study of interactions between oppositely charged dendrigraft poly-L-lysine and human serum albumin by continuous frontal analysis capillary electrophoresis and fluorescence spectroscopy [Full paper ]

  N. Sisavath, L. Leclercq, T. Le Saux, F. Oukacine, H. Cottet

  J. Chromatogr. A 2013, 1289, 127-132.

• Article • Monitoring surface functionalization of dendrigraft poly-L-lysines via click chemistry by capillary electrophoresis and Taylor dispersion analysis [Full paper ]

  T. Liu, F. Oukacine, H. Collet, A. Commeyras, L. Vial, H. Cottet

  J. Chromatogr. A 2013, 1273, 111-116.

• Article • Field enhanced bacterial sample stacking in isotachophoresis using wide-bore capillaries [Full paper ]

  F. Oukacine, J. P. Quirino, D. Destoumieux-Garzon, H. Cottet

  J. Chromatogr. A 2012, 1268, 180-184.

• Article • Taylor dispersion analysis with two detection points on a commercial capillary electrophoresis apparatus [Full paper ]

  J. Chamieh, F. Oukacine, H. Cottet

  J. Chromatogr. A 2012, 1235, 174-177.

• Article • Study of Antibacterial Activity by Capillary Electrophoresis Using Multiple UV Detection Points [Full paper ]

  F. Oukacine, B. Romestand, D. M. Goodall, G. Massiera, L. Garrelly, H. Cottet

  Anal. Chem. 2012, 84, 3302-3310.

• Article • Simultaneous Electrokinetic and Hydrodynamic Injection for High Sensitivity Bacteria Analysis in Capillary Electrophoresis [Full paper ]

  F. Oukacine, J. P. Quirino, L. Garrelly, B. Romestand, T. Zou, H. Cottet

  Anal. Chem. 2011, 83, 4949-4954.

• Article • Characterization of Carboxylated Nanolatexes by Capillary Electrophoresis [Full paper ]

  F. Oukacine, A. Morel, H. Cottet

  Langmuir 2011, 27, 4040-4047.

• Article • Focusing and Mobilization of Bacteria in Capillary Electrophoresis [Full paper ]

  F. Oukacine, L. Garrelly, B. Romestand, D. M. Goodall, T. Zou, H. Cottet

  Anal. Chem. 2011, 83, 1571-1578.

• Article • Neutral Coatings for the Study of Polycation/Multicharged Anion Interactions by Capillary Electrophoresis: Application to Dendrigraft Poly-L-lysines with Negatively Multicharged Molecules [Full paper ]

  T. Zou, F. Oukacine, T. Le Saux, H. Cottet

  Anal. Chem. 2010, 82, 7362-7368.