Serge PEREZ  

Parcours et intérêts

EDUCATION 1978 : D.Sc., University of Grenoble, France. 1973 : Doctorat, University of Bordeaux, France. 1971 : Master in Physics, University of Bordeaux, France. EXPERIENCE AND POSITIONS HELD 1996-2006 : Director, Centre de Recherches sur les Macromolécules Végétales, Centre National de la Recherche Scientifique, Grenoble, France 1987-1995 : Senior Research Scientist ( Director of Research), Institut National de la Recherche Agronomique, Nantes, France. 1984-1987 : Research Scientist, Centre National de la Recherche Scientifique, Grenoble, France. 1983-1984 : Visiting Scientist, Department of Chemistry, Research Laboratory, Eastman Kodak, Rochester, N.Y., U.S.A. 1977-1983 : Junior Research Scientist, Centre National de la Recherche Scientifique, Grenoble, France. 1974-1977 : Research Associate, Department of Chemistry, University of Montreal, P. Québec, Canada. 1973-1974 : Research Associate, Institute of Molecular Biology, University of Oregon, Eugene, Ore., U.S.A. OTHER........: Member of the French National Committee for Scientific Research (2000-2008). Elected national representative to the European Carbohydrate Organisation. (1995-99; 2000-2003) Elected chairman of the French Molecular Graphics Society (1991-94). Elected chairman of the French Carbohydrate Society (1993-95). Member of 10 scientific societies. SCIENTIFIC AREAS OF INTEREST: Structural and conformational analysis of oligo, polysaccharides and glycoconjugates in solution and in the solid state. Molecular interactions (polysaccharides-polysaccharides, protein-carbohydrates,.. Crystallography, Molecular Modeling and Graphics, NMR spectroscopy,... Enzymic hydrolysis of carbohydrates. Biotechnological applications of carbohydrates. PUBLICATIONS: > 270 publications in refereed journals > 200 oral presentations & conferences . TEACHING AREAS: 1999-2003. Director "Diplôme Etudes Approfondies" Structural and Molecular Physical Chemistry (Doctoral School : Chemistry & Life Sciences, University Joseph Fourier – Grenoble) 2003 -2006 Vice Director: Doctoral School :Chemistry & Life Science 2003 - Vice President of the Grenoble Bio-Network 2007- Director: Doctoral School: Chemistry, Life Science and Bio-Engineering EDITORIAL BOARD Journal of Carbohydrate Chemistry (1992 - …); Carbohydrate Research (1999 -2005) Biopolymers (1999 - 2006); Carbohydrates in Europe (2000) Glycoconjugate Journal (2002-) Advances in Carbohydrate Research (2004- ) ORGANISATION OF SCIENTIFIC MEETINGS: - Starch Workshop, 1988 (co-organiser). - Third Workshop on Plant Polysaccharides, Structure and Function, 1990 (co -organiser) - National Meeting of French Molecular Graphics Group, 1991. - Symposium on Conformational Studies of Oligosaccharides, Polysaccharides and Glycoconjugates, 1992. - XVèmes Journées de la Chimie et Biochimie des Glucides, 1994 - International Cereal Symposium, Nantes, 1996 (co-organiser). - 12th European Carbohydrate Symposium, Grenoble, 2003, Chairman - Workshop: Interface Physics-Plant Biology, Lyon, 2006 NATIONAL REPRESENTATIVE : European Carbohydrate Organisation (1996 - ) : International Carbohydrate Organisation (2002-2008) Chairman of the European Carbohydrate Organisation 2003-05 SCIENTIFIC COUNCILS : Chairman : Supra and Macromolecular Systems : Properties, Functions & Engineering – French National Committee of Scientific Research EUROPEAN COMMUNITY: - Member Research Training Network : « CARENET-I » (1994-1996) - Member Research Program « Biotechnology »: « Pectins … » (1994-1998) - Member Research Training Network : « CARENET-II » (1997-2000) - Member Research Training Ntework du « GlycoTrain » (2000-2003) - Coordinator Research Training Network Glycosciences (2004-2007) - Member Ressearch Training Network « GlycoNanoParticules » (2005-2008)

Serge Perez was born in Perigueux, France, and graduated, in crystallography, from the University of Bordeaux, France. He then spent one year at the Institute of Molecular Biology at the University of Oregon, Eugene, USA and subsequently three years at the Department of Chemistry at the University of Montreal, Canada. He returned to France upon accepting a permanent position as a Junior Scientist of the Centre National de le Recherche Scientifique (CNRS) at Centre de Recherches sur les Macromolecules Végétales (CERMAV), Grenoble, and he spent a sabbatical year working for Eastman Kodak in Rochester, USA. Later on, he moved on to Nantes, France, at the Institut de la Recherche Agronomique, where he was awarded a position as Senior Research Scientist to start a research group in Molecular Engineering. In January 1996 he moved back to Grenoble to become Chairman of the CERMAV, and hold this position for 11 years. He left this position to the European Synchrotron Radiation Facility to take up the position of Scientific Director in charge of the Life Sciences, Chemistry and X-ray Imaging programs. After completing his term, he returned to the CERMAV in 2012. Since January 2014 he is a staff member of the Department of Molecular Pharmacochemistry, a joint research unit between CNRS and University Joseph Fourier in Grenoble. His research interests span across the whole area of structural and conformational analysis of oligosaccharides, polysaccharides, glycoconjugates and protein–carbohydrate interactions in solution and in the solid state. This includes interests in computational chemistry and molecular modeling, crystallography, NMR spectroscopy, along with the structure-function and structure-properties relationship. He is the author of more than 280 research articles, review articles and book chapters in this area, which gave rise to about 10,500 citations. Beside his broad range interest in the field of structural glycoscience, Serge Perez is involved international and international committees related to the evaluation of scientific research and to the structuring of multilateral collaborative schemes. He is also involved in management duties at the doctoral levels and in the creation of glyco-biotechnology companies. He is also the founder of the internet site : glycopedia.eu, a recent initiative which addresses aiming at promoting the field of glycoscience throughout the publication of educational e-chapters and the publication of e-news.

Publications

• Article • Metrics of rhamnogalacturonan-I with β-(1→ 4)-linked galactan side chains and structural basis for its self-aggregation 

  ON Makshakova, TA Gorshkova, PV Mikshina, YF Zuev, S Perez

  Carbohydrate Polymers 2017, (20) 93-101

• Article • Development of Carbohydrate Nomenclature and Representation 

  S Perez, KF Aoki-Kinoshita

  A Practical Guide to Using Glycomics Databases, 7-25

• Article • Glyco3D: A Suite of Interlinked Databases of 3D Structures of Complex Carbohydrates, Lectins, Antibodies, and Glycosyltransferases 

  S Pérez, A Sarkar, A Rivet, S Drouillard, C Breton, A Imberty

  A Practical Guide to Using Glycomics Databases, 133-161

• Oral Comm • Dynamics of fucose and LewisX in lectin-binding sites 

  S Pérez, A Sarkar, A Rivet, S Drouillard, C Breton, A Imberty

• Oral Comm • Popular Glycociences 

  Serge Perez

• Article • Les biomolécules en biotechnologies 

  J.L. LENORMAND, C. DUMORT, W. RACHIDI, S. BOURGOIN, Ph. BULET, M. DE WAARD, S. PEREZ & B. PRIEM E. DROUET, R. SODOYER, J. BRETON, D. GASPARUTTO & M. SEVE

  Introduction aux biotechnologies en santé, Tome 1, S. Bourgoin-Voillard, W. Rachidi & M. Seve, Eds., Lavoisier, Tec & Doc

• Article • “Rules of Engagement” of Protein–Glycoconjugate Interactions: A Molecular View Achievable by using NMR Spectroscopy and Molecular Modeling 

  R Marchetti, S Perez, A Arda, A Imberty, J Jimenez‐Barbero, A Silipo, A Molinaro

  ChemistryOpen, 2016, (5) 274-296

• Article • The Hidden Conformation of Lewis x, a Human Histo-blood Group Antigen is a Determinant for Recognition by Pathogen Lectins 

  J Topin, M Lelimousin, J Arnaud, A Audfray, S Pérez, A Varrot,

  ACS Chem. Biol., 11, 2011−2020

• Article • The Plant Cell Walls 

  J-P. Joseleau & S. Perez

  glycopedia; www.glycopedia.eu/e-chapters/the-plant-cell-wall/article

• Oral Comm • Toolboxes for Standardized Investigations and Representations of Glycans 

  Serge Perez

• Oral Comm • Glyco Bio Informatique: Standardisation et Représentations des Carbohydrates Complexes 

  Serge Pérez

• Article • Three-Dimensional Representations of Complex Carbohydrates and Polysaccharides. SweetUnityMol: A Video Game Based Computer Graphic Software 

  S. PEREZ, T. TUBIANA, A. IMBERTY & M. BAADEN

  Glycobiology, 25, 483-491

• Article • GLYCO3D: A Portal for Structural Glycosciences [Full paper ]

  S. PEREZ, A. SARKAR, A. RIVET, C. BRETON & A. IMBERTY

  Glycoinformatics, Methods in Molecular Biology, 1273, 241-258

• Article • Databases of Conformations and NMR Structures of Glycan Determinants [Full paper ]

  A. SARKAR, S. DROUILLARD, A. RIVET & S. PEREZ (2015)

  Glycobiology, 25, 1480-1490

• Article • Negatively Charged Glyconanoparticles Modulates and Stabilize the Secondary Structures of a Gp120 V3 loop. Towards Full Synthetic HIV Vaccine Candidate 

  O. DI GIANVINCENZO, J. CALVO, S. PEREZ, A. ALVAREZ, L.M. BEDOYA, J. ALCAMI & S. PENADES

  Bioconjugate Chemistry, 26, 755-765.

• Article • Symbol Nomenclature for Graphical Representation of Glycans 

  A. VARKI, R.D. CUMMINGS, M. AEBI, N.H. PARKER, P.H. SEEBERGER,..., S. PEREZ, E. BOLTON, P. RUDD, J. PAULSON, M. KANEHISA, P. TOUKACH, K.F. AOKI-KINOSHITA, A. DELL, H. NARIMATSU, W. YORK, N. TANIGUCHI & S. KORNFELD

  Glycobiology, 25, 1323-1324

• Article • Protein-Carbohydrate interactions: Molecular Modeling Insights 

  S. Perez & I. Tvaroska

  Advances in Carbohydrate Chemistry and Biochemistry, 71, 9-136