Annabelle GEZE

Parcours et intérêts

1994 : DEA Interface Chimie Biologie, UFR Pharmacie, Montpellier I.
1999 : Doctorat d'Université en Sciences Pharmaceutiques, Université d'Angers.
1999 : Maître de Conférences, UFR Pharmacie, Université Joseph Fourier Grenoble I.
2010 : HDR, Sciences Pharmaceutiques, Université Joseph Fourier Grenoble I

Projets

• Nouveaux systèmes d'administration. Dans le cadre de ce projet inter-équipe, l'objectif est de mettre au point des systèmes intelligents d'administration de nouveaux médicaments candidats d'une part, et d'autre part de développer des formes pharmaceutiques de médicaments disponibles dans le commerce, de manière plus adaptées aux besoins du patient. Le projet associe les compétences des deux équipes de l'unité, ainsi que celles du CHU Grenoble Alpes.

Publications

• Article • Biopharmaceutical Assessment of Dexamethasone Acetate-Based Hydrogels Combining Hydroxypropyl Cyclodextrins and Polysaccharides for Ocular Delivery [Full paper ]

  azet, R. Garcia-Otero, X. Choisnard, L. Wouessidjewe, D. Verdoot, V. Bossard, F. Diaz-Tome, V. Blanc-Marquis, V. Otero-Espinar, F. J. Fernandez-Ferreiro, A. Geze, A.

  Pharmaceutics 2020, 12 (8), 717

• Article • Biodistribution and preliminary toxicity studies of nanoparticles made of Biotransesterified β–cyclodextrins and PEGylated phospholipids [Full paper ]

  P. Perret, S. Bacot, A. Gèze, A. Gentil Dit Maurin, M. Debiossat, A. Soubies, V. Blanc-Marquis, L. Choisnard, J. Boutonnat, C. Ghezzi, J.L. Putaux, C. Lancelon-Pin, L.M. Riou,⁎, D. Wouessidjewe

  Materials Science & Engineering C 2018, 85, 7-17

• Article • Investigation of Combined Cyclodextrin and Hydrogel Formulation for Ocular Delivery of Dexamethasone Acetate by Means of Experimental Designs 

  Roseline Mazet , Luc Choisnard , Delphine Levilly , Denis Wouessidjewe and Annabelle Gèze

  Pharmaceutics, 2018 , 10 , 249

• Article • Self-assembly of amphiphilic biotransesterified B-cyclodextrins : supramolecular structure of nanoparticles and surface properties [Full paper ]

  Jean-Luc Putaux, Christine Lancelon-Pin, François-Xavier Legrand, Marion Pastrello, Luc Choisnard, Annabelle Gèze, Cyrille Rochas and Denis Wouessidjewe

  Langmuir 2017, 33, 7917–7928

• Article • New nanoparticles obtained by co-​assembly of amphiphilic cyclodextrins and nonlamellar single-​chain lipids: Preparation and characterization [Full paper ]

  Nguyen, C-H ; Putaux, J-L; Santoni, G; Tfaili, S; Fourmentin, S; Coty, J-B; Choisnard, L; Geze, A; Wouessidjewe, D; Barratt, G; Lesieur, S; Legrand, F-X

  Int. J. Pharm. 2017, 531(2), 444-456

• Article • Biocompatible Double-Membrane Hydrogels from Cationic Cellulose Nanocrystals and Anionic Alginate as Complexing Drugs Codelivery [Full paper ]

  Ning Lin, Annabelle Gèze, Denis Wouessidjewe, Jin Huang, and Alain Dufresne

  ACS Applied Materials & Interfaces 2016, 8(11), 6880-6889

• Article • Mesoporous self-​assembled nanoparticles of biotransesterified cyclodextrins and nonlamellar lipids as carriers of water-​insoluble substances [Full paper ]

  Zerkoune, Leila; Lesieur, Sylviane; Putaux, Jean-Luc; Choisnard, Luc; Geze, Annabelle; Wouessidjewe, Denis; Angelov, Borislav; Vebert-Nardin, Corinne; Doutch, James; Angelova, Angelina

  Soft Matter, 2016, 12, 7539-7550

• Article • Progress in developing amphiphilic cyclodextrin-based nanodevices for drug delivery 

  J. Yameogo, A. Geze, L. Choisnard, J-L. Putaux, S. Semde, D. Wouessidjewe

  Current Topics in medicinal chemistry, 14, 526-541

• Article • Self-assembled biotransesterified cyclodextrins as potential Artemisinin nanocarriers. II: In vitro behavior toward the immune system and in vivo biodistribution assessment of unloaded nanoparticles [Full paper ]

  J. B.G. Yaméogo, A. Gèze, L. Choisnard, J-L Putaux, R. Mazet, C. Passirani, M. Keramidas, J-L Coll, N. Lautram, J. Bejaud, R. Semdé, D. Wouessidjewe

  European Journal of pharmaceutics and biopharmaceutics, 88, 683-694

• Article • Topological defects in polycrystalline hexosomes from β-cyclodextrin fatty esters [Full paper ]

  Putaux, J. L. Lancelon-Pin, C. Choisnard, L. Gèze, A. Wouessidjewe, D.

  Soft Matter, 2022, 18, 2028-2038

• Article • Pharmacokinetic study of intravenously administered artemisinin-loaded surface-decorated amphiphilic γ-cyclodextrin nanoparticles [Full paper ]

  J. Boumbéwendin Gérard Yaméogo, R. Mazet, D. Wouessidjewe, L. Choisnard, D. Godin-Ribuot, J.-L. Putaux, R. Semdé, A. Gèze

  Mat. Sci. Engin. C 2020, 106, 110281

• Article • Recent Advances in the Design of Topical Ophthalmic Delivery Systems in the Treatment of Ocular Surface Inflammation and Their Biopharmaceutical Evaluation 

  Mazet, R. Yameogo, J. B. G. Wouessidjewe, D. Choisnard, L. Geze, A.

  Pharmaceutics, 2020, 12 (6), 570

• Article • Capillary electrophoretic apparatus for the endpoint detection in microtitration methods [Full paper ]

  F. Oukacine, L. Choisnard, A. Gèze, E. Peyrin

  J. Chromatogr. A, 2019

• Article • Inline coupling of electrokinetic preconcentration method to Taylor dispersion analysis for size-based characterization of low-UV-absorbing nanoparticles [Full paper ]

  F. Oukacine, A. Gèze, L. Choisnard, JL. Putaux, JP. Stahl, E. Peyrin

  Anal. Chem. 2018, 90, 2493–2500

• Article • Quantitative evaluation of the combination between cytotoxic drug and efflux transporter inhibitors based on a tumour growth inhibition model 

  A. Sostelly, L. Payen, J. Guitton, A. Di Pietro, P. Falson, M. Honorat, A. Boumendjel, A. Geze, G. Freyer, M. Tod

  Fundamental & Clinical Pharmacology, 2014, 28, 161-9.

• Article • A template model for studying anticancer drug efflux transporter inhibitors in vitro. 

  A. Sostelly, L. Payen, J. Guitton, A. Di Pietro, P. Falson, M. Honorat, G. Valdamieri, A. Geze, A. Boumendjel, G. Freyer, M. Tod

  Fundamental & Clinical Pharmacol. 2013, 27, 544-56.

• Article • Bioesterified polysubstituted-cycloedxtrin/surfactant nanoparticles obtained by multilevel self-assembly 

  L.Zerkoune, A. Angelova, L. Choisnard, A. Gèze, D. Wouessidjewe, S. Lesieur

  ICOMF14 Proceedings, MATEC Web of conferences, 2013, 4, 05001

• Article • Monodisperse nanoparticles from self-assembling amphiphilic cyclodextrin: modulable tools for the encapsulation and controlled release of pharmaceuticals 

  A. Mendez-Ardoy, M. Gomez Garcia, A. Geze, J.-L. Putaux, D. Wouessidjewe, C. Ortiz Mellet, J. Defaye, J. M. Garcia Fernandez, J. M. Benito

  Med. Chem. 2012, 8, 524-532.

• Article • Self-assembled biotransesterified cyclodextrins as artemisinin nanocarriers - I : Formulation, lyoavailability and in vitro antimalarial activity assessment 

  Josias B.G. Yameogo, c, Annabelle Geze, , Luc Choisnard, Jean-Luc Putaux, Adama Gansane, Sodiomon B. Sirimad, Rasmane Semde, Denis Wouessidjewe

  Eur. J. Pharm. Biopharm, 2012, 80(3), 508-517.

• Article • Physicochemical Characterization of of a-, β-, and γ-Cyclodextrins Bioesterified with Decanoate Chains Used As Building Blocks of Colloidal Nanoparticles 

  L. Choisnard, A. Gèze, C. Vanhaverbeke, J. B. G. Yamogo, J.-L. Putaux, B. Brasme, L. Jullien, S. Boullanger, C. Elfakir, D. Wouessidjewe

  Biomacromolecules, 2011, 12(8), 3031-3038.

• Article • The acridone derivative MBLI-87 reverses breast cancer resistance protein-mediated resistance to irinotecan in xenografts. 

  O. Arnaud, A. Boumendjel, A. Geze, P. Falson, C. Dumontet, A. Di Pietro, L. Payen

  Eur. J. Cancer, 2011, 47, 640-648.

• Article • The acridone derivative MBLI-87 reverses breast cancer resistance protein-mediated resistance to irinotecan in xenografts. 

  O. Arnaud, A. Boumendjel, A. Geze, P. Falson, C. Dumontet, A. Di Pietro, L. Payen

  E. J. Cancer, 2011, 47, 640-648.

• Article • Colloidal systems made of biotransesterified alpha, beta, and gamma cyclodextrins grafted with C10 alkyl chains 

  A. Geze, L. Choisnard, J-L. Putaux, D. Wouessidjewe

  Materials science and engineering, 2009 ,C29,458-462

• Article • Antimitotic and antiproliferative activities of chalcones: Forward structure-activity relationship 

  A. Boumendjel, E. Nicolle, P.-A. Carrupt, J. Boccard, M. Blanc, A. Geze, L. Choisnard, D. Wouessidgewe, C. Dumontet

  J. Med. Chem. 2008, 51, 2307-2310.

• Article • Characterisation of complex amphiphilic cyclodextrin mixtures by high-performance liquid chromatography and mass spectrometry. 

  F. Kieken, C. West, K. Keddadouche, C. Elfakir, L. Choisnard, A. Gèze, D. Wouessidjewe

  J. Chrom. A, 2008, 1189, 385-391.

• Article • Miscellaneous nanoaggregates made of beta-CD esters synthesised by an enzymatic pathway 

  L. Choisnard, A. Geze, B.G.J. Yaméogo, J-L. Putaux, D. Wouessidjewe

  Int. J. Pharm. 2007, 344, 26-32.

• Article • Biodistribution of intravenously administered amphiphilic beta-cyclodxetrin nanospheres 

  A. Geze, L. Tieu Chau, L. Choisnard, J.-P. Mathieu, D. Marti-Batlle, L. Riou, J.-P. Putaux, D. Wouessidjewe

  Int. J. Pharm. 2007, 344, 135-142.

• Article • Poudres, granulés et comprimés dans Pharmacie Galénique : Formulation et technologie Pharmaceutique 

  V. Busignies, D. Chulia, L. Choisnard, R. de Challemaison, A. Geze, S. Stainmesse, J. Siepmann, P. Tchoreloff, M. Viana, P. Wehrlé, D. Wouessidjewe,

  Editions Maloine 2007, Chapitre 2, 1-45.

• Article • Formes galéniques en développement dans Pharmacie Galénique : Formulation et technologie Pharmaceutique 

  S. Begu, A. Bochot, L. Choisnard, P. Couvreur, D. Duchene, F. Edwards, E. Fattal, A. Geze, G. Ponchel, V. Preat, C. Tourne-Petaeille, D. Wouessidjewe

  Editions Maloine. 2007, Chapitre 8, 1-36.

• Book • Pharmacie Galénique : Formulation et technologie Pharmaceutique 

  poudres, granulés et comprimés dans Pharmacie Galénique

  V. Busignies, D. Chulia, L. Choisnard, R. de Challemaison, A. Gèze, S. Stainmesse, J. Siepmann, P. Tchoreloff, M. Viana, P. Wehrlé, D. Wouessidjewe

  2007 • 1-44, Maloine - Paris

• Book • Pharmacie Galenique : Formulation et technologie pharmaceutique 

  Formes galéniques en développement dans Pharmacie Galénique

  S. Begu, A. Bochot, L. Choisnard, P. Couvreur, D. Duchene, F. Edwards, E. Fattal, A. Geze, G. Ponchel, V. Preat, C. Tourné-Peteilh, D. Wouessidjewe

  2007 • 250-289, Maloine - Paris

• Article • Nanoparticles of b-cyclodextrin esters obtained by self-assembling of biotransesterified b-cyclodextrin 

  L. Choisnard, A. Geze, J.L. Putaux, Y.S. Wong, D. Wouessidjewe

  Biomacromolecules 2006, 7, 515-520.

• Patent • Preparation of nanosphere amphiphilic cyclodextrin derivatives as biological transporters 

  J. Defaye, P. Balbuena, J.M. Benito, A. Diaz Moscoso, C. Di Giorgio, J.M. Garcia Fernandez, A. Geze, M. Gomez Garcia, C. Ortiz Mellet, P. Vierling, D. Wouessidjewe

  2006 • CNRS

• Article • Efficient size control of amphiphilic cyclodextrin nanoparticles through a statistical mixture design methodology. 

  L. Choisnard, A. Geze, M. Bigan, J. L. Putaux, D. Wouessidjewe

  J. Pharm. Pharmaceut. Sci. 2005, 8, 593-600

• Article • Conformational states and thermodynamics of a-lactalbumin bound to membranes: a case study of the effects of pH, calcium, lipid membrane curvature and charge 

  A. Chenal, G. Vernier, P. Savarin, N.A. Bushmarina, A. Geze, F. Guillain, D. Gillet, V. Forge

  J. Mol. Biol. 349, 2005, 890-905

• Article • Long term stability study of amphiphilic b-cyclodextrin nanosphere suspensions monitored by dynamic light scattering and cryo-transmission electron microscopy 

  A. Gèze, J.-L. Putaux, L. Choisnard, P. Jéhan, D. Wouessidjewe

  J. Microencapsul. 2004, 21, 607-613.

• Article • Influence of chemical structure of amphiphilic b-cyclodextrins on their ability to form stable nanoparticles 

  A. Gèze, S. Aous, I. Baussanne, J.-L. Putaux, J. Defaye, D. Wouessidjewe

  Int. J. Pharm. 2002, 242, 301-305.

• Article • Stoichiometry and formation constants of six PAHs with gamma-cyclodextrin determined by high performance liquid chromatography using a cyano stationary phase 

  C. Ravelet, A. Ravel, C. Grosset, A. Villet, A. Geze, D. Wouessidjewe, E. Peyrin

  J. Liq. Chromatogr. Relat. Technol. 2002, 25, 421-432

• Article • Chromatographic determination of the association constants between nimesulide and native and modified beta-cyclodextrins 

  C. Ravelet, A. Geze, A. Villet, C. Grosset, A. Ravel D. Wouessidjewe, E. Peyrin

  J. Pharm. Biomed. Anal. 2002, 29, 425-429

• Article • PLGA microsphere bioburden evaluation for radiosterilization dose selection 

  A. Gèze, M.-C. Venier-Julienne, J. Cottin, N. Faisant, J.-P. Benoit

  J. Microencapsul. 2001, 18, 627-636.