Luc CHOISNARD

Maître de conférences au DPM depuis le 01-09-2002

Bureau : E207

rf.sepla-elbonerg-vinu@dransiohC.cuL

Tel : 0476635301

Fax : 0476635298

 Equipe « NOVA »

Parcours et intérêts

2000 : thèse de doctorat Génie enzymatique, Bioconversion et Microbiologie.
2000-2002 : ATER à l'IUP QEPI Univ. Science et techn. de Lille.
2002 : MCF Grenoble pharmacie.

Projets

  • Nouveaux systèmes d'administration. Dans le cadre de ce projet inter-équipe, l'objectif est de mettre au point des systèmes intelligents d'administration de nouveaux médicaments candidats d'une part, et d'autre part de développer des formes pharmaceutiques de médicaments disponibles dans le commerce, de manière plus adaptées aux besoins du patient. Le projet associe les compétences des deux équipes de l'unité, ainsi que celles du CHU Grenoble Alpes.

  • Mise au point de dispositifs d'analyse innovants. Ce projet comprend deux volets : d'une part, il s'agit de développer des tests de diagnostic faciles à utiliser, rapides, peu coûteux et/ou portables à l'aide d'aptamères, afin de facilité les soins aux patients ou de détecter les contaminants environnementaux ; d'autre part, l'objectif est d'établir de nouvelles stratégies de signalement pour le développement de dispositifs à haut débit et/ou haute sensibilité.

Publications

  • Article • Pharmacokinetic study of intravenously administered artemisinin-loaded surface-decorated amphiphilic γ-cyclodextrin nanoparticles [Full paper ]

    J. Boumbéwendin Gérard Yaméogo, R. Mazet, D. Wouessidjewe, L. Choisnard, D. Godin-Ribuot, J.-L. Putaux, R. Semdé, A. Gèze

    Mat. Sci. Engin. C 2020, 106, 110281

  • Article • Biodistribution and preliminary toxicity studies of nanoparticles made of Biotransesterified β–cyclodextrins and PEGylated phospholipids [Full paper ]

    P. Perret, S. Bacot, A. Gèze, A. Gentil Dit Maurin, M. Debiossat, A. Soubies, V. Blanc-Marquis, L. Choisnard, J. Boutonnat, C. Ghezzi, J.L. Putaux, C. Lancelon-Pin, L.M. Riou,⁎, D. Wouessidjewe

    Materials Science & Engineering C 2018, 85, 7-17

  • Article • Investigation of Combined Cyclodextrin and Hydrogel Formulation for Ocular Delivery of Dexamethasone Acetate by Means of Experimental Designs 

    Roseline Mazet , Luc Choisnard , Delphine Levilly , Denis Wouessidjewe and Annabelle Gèze

    Pharmaceutics, 2018 , 10 , 249

  • Article • Self-assembly of amphiphilic biotransesterified B-cyclodextrins : supramolecular structure of nanoparticles and surface properties [Full paper ]

    Jean-Luc Putaux, Christine Lancelon-Pin, François-Xavier Legrand, Marion Pastrello, Luc Choisnard, Annabelle Gèze, Cyrille Rochas and Denis Wouessidjewe

    Langmuir 2017, 33, 7917–7928

  • Article • New nanoparticles obtained by co-​assembly of amphiphilic cyclodextrins and nonlamellar single-​chain lipids: Preparation and characterization [Full paper ]

    Nguyen, C-H ; Putaux, J-L; Santoni, G; Tfaili, S; Fourmentin, S; Coty, J-B; Choisnard, L; Geze, A; Wouessidjewe, D; Barratt, G; Lesieur, S; Legrand, F-X

    Int. J. Pharm. 2017, 531(2), 444-456

  • Article • Mesoporous self-​assembled nanoparticles of biotransesterified cyclodextrins and nonlamellar lipids as carriers of water-​insoluble substances [Full paper ]

    Zerkoune, Leila; Lesieur, Sylviane; Putaux, Jean-Luc; Choisnard, Luc; Geze, Annabelle; Wouessidjewe, Denis; Angelov, Borislav; Vebert-Nardin, Corinne; Doutch, James; Angelova, Angelina

    Soft Matter, 2016, 12, 7539-7550

  • Article • Progress in developing amphiphilic cyclodextrin-based nanodevices for drug delivery 

    J. Yameogo, A. Geze, L. Choisnard, J-L. Putaux, S. Semde, D. Wouessidjewe

    Current Topics in medicinal chemistry, 14, 526-541

  • Article • Self-assembled biotransesterified cyclodextrins as potential Artemisinin nanocarriers. II: In vitro behavior toward the immune system and in vivo biodistribution assessment of unloaded nanoparticles [Full paper ]

    J. B.G. Yaméogo, A. Gèze, L. Choisnard, J-L Putaux, R. Mazet, C. Passirani, M. Keramidas, J-L Coll, N. Lautram, J. Bejaud, R. Semdé, D. Wouessidjewe

    European Journal of pharmaceutics and biopharmaceutics, 88, 683-694

  • Article • Inline coupling of electrokinetic preconcentration method to Taylor dispersion analysis for size-based characterization of low-UV-absorbing nanoparticles 

    F. Oukacine, A. Gèze, L. Choisnard, JL. Putaux, JP. Stahl, E. Peyrin

    Anal. Chem. 2018, 90, 2493–2500

  • Article • Colorimetric nanosensor based on a selective target-responsive aptamer kissing complex 

    E. Goux, E. Dausse, V. Guieu, L. Azéma, G. Durand, M. Henry, L. Choisnard, J-J. Toulmé, C. Ravelet, E. Peyrin

    Nanoscale, 2017, 9, 4048 - 4052.

  • Article • Stability of catecholamines in whole blood: Influence of time between collection and centrifugation 

    Q. Despinasse, L. Choisnard, P. Faure, D. Guicherd, E. Peyrin, C. Ravelet, B. Chovelon

    Clinical Chemistry and Laboratory Medicine, 2021, 59, E83-E85

  • Article • Crystal and molecular structure of V-amylose complexed with ibuprofen [Full paper ]

    Cong Anh Khanh Le, Yu Ogawa a, Frédéric Dubreuil, Florent Grimaud, Karim Mazeau, Gregory R. Ziegler, Shivalika Tanwar, Yoshiharu Nishiyama, Gabrielle Potocki-Veronese, Luc Choisnard, Denis Wouessidjewe, Jean-Luc Putaux

    Carbohydrate Polymers, 2021, 261, 117885

  • Article • Capillary electrophoretic apparatus for the endpoint detection in microtitration methods [Full paper ]

    F. Oukacine, L. Choisnard, A. Gèze, E. Peyrin

    J. Chromatogr. A, 2019

  • Article • Single Crystals of V-Amylose Complexed with Bicyclic Organic Compounds. Special Issue: Polymer‐Solvent Complexes and Intercalates  [Full paper ]

    Cong‐Anh‐Khanh Le Luc Choisnard Denis Wouessidjewe Jean‐Luc Putaux

    MACROMOLECULAR SYMPOSIA

  • Article • Urinary trans-anti-7,8,9,10-tetrahydroxy-7,8,9,10-tetrahydrobenzo(a) pyrene as the most relevant biomarker for assessing carcinogenic polycyclic aromatic hydrocarbons exposure [Full paper ]

    Damien Barbeau, Simon Lutier, Luc Choisnard, Marie Marques, Renaud Persoons, Anne Maitre

    Environment International, 2018, 112, 147–155

  • Article • Polymorphism of crystalline complexes of V-amylose with fatty acids [Full paper ]

    Cong-Anh-Khanh Le, Luc Choisnard, Denis Wouessidjewe, Jean-Luc Putaux

    International Journal of Biological Macromolecules 2018,119, 555-564

  • Oral Comm • Le nettoyeur à vapeur a-t-il une place dans la prise en charge des dispositifs médicaux réutilisables à corps creux en stérilisation? 

    A. Bros, R. Mazet, L. Choisnard, N. Sylvoz, P. Bedouch, C. Guimier-Pingault

  • Article • The water test could be a good indication to evaluate the effectiveness of the sterile barrier system of rigid sterilization containers. [Full paper ]

    L. Decarout, C. Lambert, L. Choisnard, C. Andonian, C. Fayard

    Annales Pharmaceutiques Françaises, 2018, 76(6), 464-472

  • Book • Validation de la robustesse d'une methode analytique par plan d'experiences 

    Morgan Germa, Luc Choisnard

    2015 • 1-4, - Paris

  • Article • Bioesterified polysubstituted-cycloedxtrin/surfactant nanoparticles obtained by multilevel self-assembly 

    L.Zerkoune, A. Angelova, L. Choisnard, A. Gèze, D. Wouessidjewe, S. Lesieur

    ICOMF14 Proceedings, MATEC Web of conferences, 2013, 4, 05001

  • Article • Self-assembled biotransesterified cyclodextrins as artemisinin nanocarriers - I : Formulation, lyoavailability and in vitro antimalarial activity assessment 

    Josias B.G. Yameogo, c, Annabelle Geze, , Luc Choisnard, Jean-Luc Putaux, Adama Gansane, Sodiomon B. Sirimad, Rasmane Semde, Denis Wouessidjewe

    Eur. J. Pharm. Biopharm, 2012, 80(3), 508-517.

  • Article • Physicochemical Characterization of of a-, β-, and γ-Cyclodextrins Bioesterified with Decanoate Chains Used As Building Blocks of Colloidal Nanoparticles 

    L. Choisnard, A. Gèze, C. Vanhaverbeke, J. B. G. Yamogo, J.-L. Putaux, B. Brasme, L. Jullien, S. Boullanger, C. Elfakir, D. Wouessidjewe

    Biomacromolecules, 2011, 12(8), 3031-3038.

  • Article • Forming Spirocyclohexadienone-oxocarbenium cation species in the biomimetic synthesis of amomols. 

    M. Traore, M. Maynadier, F. Souard, L. Choisnard, H. Vial, Y.-S. Wong

    J. Org. Chem. 2011, 76, 1409-1417.

  • Article • Colloidal systems made of biotransesterified alpha, beta, and gamma cyclodextrins grafted with C10 alkyl chains 

    A. Geze, L. Choisnard, J-L. Putaux, D. Wouessidjewe

    Materials science and engineering, 2009 ,C29,458-462

  • Article • Antimitotic and antiproliferative activities of chalcones: Forward structure-activity relationship 

    A. Boumendjel, E. Nicolle, P.-A. Carrupt, J. Boccard, M. Blanc, A. Geze, L. Choisnard, D. Wouessidgewe, C. Dumontet

    J. Med. Chem. 2008, 51, 2307-2310.

  • Article • Characterisation of complex amphiphilic cyclodextrin mixtures by high-performance liquid chromatography and mass spectrometry. 

    F. Kieken, C. West, K. Keddadouche, C. Elfakir, L. Choisnard, A. Gèze, D. Wouessidjewe

    J. Chrom. A, 2008, 1189, 385-391.

  • Article • Poudres, granulés et comprimés dans Pharmacie Galénique : Formulation et technologie Pharmaceutique 

    V. Busignies, D. Chulia, L. Choisnard, R. de Challemaison, A. Geze, S. Stainmesse, J. Siepmann, P. Tchoreloff, M. Viana, P. Wehrlé, D. Wouessidjewe,

    Editions Maloine 2007, Chapitre 2, 1-45.

  • Article • Formes galéniques en développement dans Pharmacie Galénique : Formulation et technologie Pharmaceutique 

    S. Begu, A. Bochot, L. Choisnard, P. Couvreur, D. Duchene, F. Edwards, E. Fattal, A. Geze, G. Ponchel, V. Preat, C. Tourne-Petaeille, D. Wouessidjewe

    Editions Maloine. 2007, Chapitre 8, 1-36.

  • Article • Miscellaneous nanoaggregates made of beta-CD esters synthesised by an enzymatic pathway 

    L. Choisnard, A. Geze, B.G.J. Yaméogo, J-L. Putaux, D. Wouessidjewe

    Int. J. Pharm. 2007, 344, 26-32.

  • Article • Biodistribution of intravenously administered amphiphilic beta-cyclodxetrin nanospheres 

    A. Geze, L. Tieu Chau, L. Choisnard, J.-P. Mathieu, D. Marti-Batlle, L. Riou, J.-P. Putaux, D. Wouessidjewe

    Int. J. Pharm. 2007, 344, 135-142.

  • Book • Pharmacie Galénique : Formulation et technologie Pharmaceutique 

    poudres, granulés et comprimés dans Pharmacie Galénique

    V. Busignies, D. Chulia, L. Choisnard, R. de Challemaison, A. Gèze, S. Stainmesse, J. Siepmann, P. Tchoreloff, M. Viana, P. Wehrlé, D. Wouessidjewe

    2007 • 1-44, Maloine - Paris

  • Book • Pharmacie Galenique : Formulation et technologie pharmaceutique 

    Formes galéniques en développement dans Pharmacie Galénique

    S. Begu, A. Bochot, L. Choisnard, P. Couvreur, D. Duchene, F. Edwards, E. Fattal, A. Geze, G. Ponchel, V. Preat, C. Tourné-Peteilh, D. Wouessidjewe

    2007 • 250-289, Maloine - Paris

  • Article • Nanoparticles of b-cyclodextrin esters obtained by self-assembling of biotransesterified b-cyclodextrin 

    L. Choisnard, A. Geze, J.L. Putaux, Y.S. Wong, D. Wouessidjewe

    Biomacromolecules 2006, 7, 515-520.

  • Article • Experimental design optimization for screening relvant free phenolic acids from various preparations used in Burkina Faso folk medicine 

    M. Kienbrebego, L. Choisnard, C. E. Lamien, A. Meda, D. Wouessidjewe, O. Nacoulma

    Afr. J. Trad. Comp. Alt. Med. 2006, 3, 115-128.

  • Article • Efficient size control of amphiphilic cyclodextrin nanoparticles through a statistical mixture design methodology. 

    L. Choisnard, A. Geze, M. Bigan, J. L. Putaux, D. Wouessidjewe

    J. Pharm. Pharmaceut. Sci. 2005, 8, 593-600

  • Article • Optimization of the preparation of aqueous suspensions of waxy maize starch nanocrystals using a response surface methodology. 

    H. Angellier, L. Choisnard, S. Molina-Boisseau, P. Ozil, A. Dufresne

    Biomacromolecules 2004, 5, 1545-1551.

  • Article • Long term stability study of amphiphilic b-cyclodextrin nanosphere suspensions monitored by dynamic light scattering and cryo-transmission electron microscopy 

    A. Gèze, J.-L. Putaux, L. Choisnard, P. Jéhan, D. Wouessidjewe

    J. Microencapsul. 2004, 21, 607-613.

  • Article • Application of the method of the experimental design to the study of a processing of unshrinkableness of wool fibers 

    L. Choisnard, M. Bigan, D. Blondeau, P. Dhulster, B. Leman, D. Guillochon

    J. Applied Polym. Sci. 2003, 89, 535-547.

  • Article • Kinetic study of the appearance of an antibacterial peptide in the course of bovine haemoglobin peptic hydrolysis 

    L. Choisnard, R. Froidevaux, B. Lignot, N. Nedjar-Arroume, D. Vercaigne-Marko, F. Krier, P. Dhulster, D. Guillochon

    Biotechnol. Appl. Biochem. 2002, 36, 187-194.

  • Article • Advancement in intermediate opioid peptide production in an enzymatic membrane reactor assisted by solvent extraction 

    P. Dhulster, R. Kapel, R. Froidevaux, N. Nedjar-arroume, A. Fertin-Bazus, L. Choisnard, D. Guillochon

    Desalination 2002, 148, 221-226.