Maître de conférences au DPM depuis le 01-09-2002

Bureau : E207


04 76 63 53 01

 Equipe « NOVA »

Parcours et intérêts

2000 : thèse de doctorat Génie enzymatique, Bioconversion et Microbiologie.
2000-2001 : Ingénieur R&D groupe Chargeur
2001-2002 : ATER à l'IUP QEPI Univ. Science et techn. de Lille.
2002 : MCF Grenoble pharmacie.


  • Nouveaux systèmes d'administration. Dans le cadre de ce projet inter-équipe, l'objectif est de mettre au point des systèmes intelligents d'administration de nouveaux médicaments candidats d'une part, et d'autre part de développer des formes pharmaceutiques de médicaments disponibles dans le commerce, de manière plus adaptées aux besoins du patient. Le projet associe les compétences des deux équipes de l'unité, ainsi que celles du CHU Grenoble Alpes.

  • Mise au point de dispositifs d'analyse innovants. Ce projet comprend deux volets : d'une part, il s'agit de développer des tests de diagnostic faciles à utiliser, rapides, peu coûteux et/ou portables à l'aide d'aptamères, afin de facilité les soins aux patients ou de détecter les contaminants environnementaux ; d'autre part, l'objectif est d'établir de nouvelles stratégies de signalement pour le développement de dispositifs à haut débit et/ou haute sensibilité.


  • Article • Stability of fecal calprotectin extracts using the Diasorin® kit [Full paper ]

    B. Billet, L. Choisnard, P. Faure, D. Guicherd, E. Cussigh, E. Peyrin, C. Ravelet, B. Chovelon

    Clin. Chem. Lab. Med. 2024, 62, e13–e15

  • Article • Validation of HPLC and TLC analytical methods to determine radiochemical purity of 99mTc-cAbVCAM1-5, a new experimental radiotracer 

    Leenhardt, J. Mutin, J. Choisnard, L. Orhon, P. Lassiaz, M. Bacot, S. Ahmadi, M. De Leiris, N. Djaileb, L. Broisat, A. Ghezzi, C. Bedouch, P. Brunet, M. D.

  • Article • Comparative study of production and control processes of parenteral nutritional admixtures in neonatology [Full paper ]

    Bosson, A. Durand, M. Mazet, R. Jouannet-Romaszko, M. Chennell, P. Mounsef, F. Quessada, T. Choisnard, L. Bedouch, P.

    Ann Pharm Fr, 2024, 82,306-317

  • Article • Bacterial survival in radiopharmaceutical solutions: a critical impact on current practices [Full paper ]

    J. Leenhardt, L. Choisnard, M. Plasse, V. Ardisson, N. de Leiris, L. Djaileb, P. Bedouch, M.-D. Brunet

    EJNMMI Radiopharm. Chem. 2023

  • Article • COVID-19 mass vaccination - an illustration of the impact of syringe choice on the effectiveness of mass vaccination campaigns [Full paper ]

    Mazet R., Choisnard L., Leenhardt J., Epaulard O., Brudieu E., Bedouch P.

    Emerg Microbes Infect, 2022, 11, 804-806

  • Article • A quality by design approach for the qualification of automating compounding device for parenteral nutrition [Full paper ]

    Quentin Perrier, Marie Piquemal, Julien Leenhardt, Luc Choisnard, Roseline Mazet, Marie-Dominique Desruet, Marjorie Durand, Pierrick Bedouch

    European Journal of Pharmaceutical Sciences, 2022,179: 106275

  • Article • Stability of catecholamines in whole blood: Influence of time between collection and centrifugation [Full paper ]

    Q. Despinasse, L. Choisnard, P. Faure, D. Guicherd, E. Peyrin, C. Ravelet, B. Chovelon

    Clin. Chem. Lab. Med. 2021, 59, e83 85

  • Article • Simultaneous analysis of PAH urinary mono- and dihydroxylated metabolites by GC-MS-MS following SPE and two-stage derivatization [Full paper ]

    M. Marques, A. Maitre, L. Choisnard, C. Demeilliers, R. Persoons

    Anal. Bioanal. Chem. 2021, 413, 6823 6835

  • Article • Quantification of ions and organic molecules, in nanoliter samples, in the absence of reference materials [Full paper ]

    L. Lavigne, L. Choisnard, E. Peyrin, F. Oukacine

    Anal. Chem. 2022, 94, 15546−15552

  • Article • Polymorphism of V-Amylose Cocrystallized with Aliphatic Diols [Full paper ]

    C. Anh Khanh Le, L. Choisnard, D. Wouessidjewe, J.-L. Putaux

    Polymer 2021, 213, 123302

  • Article • Crystal and Molecular Structure of V-Amylose Complexed with Ibuprofen [Full paper ]

    C. Anh Khanh Le, Y. Ogawa, F. Dubreuil, F. Grimaud, K. Mazeau, G. R. Ziegler, S. Tanwar, Y. Nishiyama, G. Potocki-Veronese, L. Choisnard, D. Wouessidjewe, J.-L. Putaux

    Carbohydr. Polym. 2021, 261, 117885

  • Article • Biopharmaceutical Assessment of Dexamethasone Acetate-Based Hydrogels Combining Hydroxypropyl Cyclodextrins and Polysaccharides for Ocular Delivery [Full paper ]

    azet, R. Garcia-Otero, X. Choisnard, L. Wouessidjewe, D. Verdoot, V. Bossard, F. Diaz-Tome, V. Blanc-Marquis, V. Otero-Espinar, F. J. Fernandez-Ferreiro, A. Geze, A.

    Pharmaceutics 2020, 12 (8), 717

  • Article • Biodistribution and preliminary toxicity studies of nanoparticles made of Biotransesterified β–cyclodextrins and PEGylated phospholipids [Full paper ]

    P. Perret, S. Bacot, A. Gèze, A. Gentil Dit Maurin, M. Debiossat, A. Soubies, V. Blanc-Marquis, L. Choisnard, J. Boutonnat, C. Ghezzi, J.L. Putaux, C. Lancelon-Pin, L.M. Riou,⁎, D. Wouessidjewe

    Materials Science & Engineering C 2018, 85, 7-17

  • Article • Investigation of Combined Cyclodextrin and Hydrogel Formulation for Ocular Delivery of Dexamethasone Acetate by Means of Experimental Designs 

    Roseline Mazet , Luc Choisnard , Delphine Levilly , Denis Wouessidjewe and Annabelle Gèze

    Pharmaceutics, 2018 , 10 , 249

  • Article • Self-assembly of amphiphilic biotransesterified B-cyclodextrins : supramolecular structure of nanoparticles and surface properties [Full paper ]

    Jean-Luc Putaux, Christine Lancelon-Pin, François-Xavier Legrand, Marion Pastrello, Luc Choisnard, Annabelle Gèze, Cyrille Rochas and Denis Wouessidjewe

    Langmuir 2017, 33, 7917–7928

  • Article • New nanoparticles obtained by co-​assembly of amphiphilic cyclodextrins and nonlamellar single-​chain lipids: Preparation and characterization [Full paper ]

    Nguyen, C-H ; Putaux, J-L; Santoni, G; Tfaili, S; Fourmentin, S; Coty, J-B; Choisnard, L; Geze, A; Wouessidjewe, D; Barratt, G; Lesieur, S; Legrand, F-X

    Int. J. Pharm. 2017, 531(2), 444-456

  • Article • Mesoporous self-​assembled nanoparticles of biotransesterified cyclodextrins and nonlamellar lipids as carriers of water-​insoluble substances [Full paper ]

    Zerkoune, Leila; Lesieur, Sylviane; Putaux, Jean-Luc; Choisnard, Luc; Geze, Annabelle; Wouessidjewe, Denis; Angelov, Borislav; Vebert-Nardin, Corinne; Doutch, James; Angelova, Angelina

    Soft Matter, 2016, 12, 7539-7550

  • Article • Progress in developing amphiphilic cyclodextrin-based nanodevices for drug delivery 

    J. Yameogo, A. Geze, L. Choisnard, J-L. Putaux, S. Semde, D. Wouessidjewe

    Current Topics in medicinal chemistry, 14, 526-541

  • Article • Self-assembled biotransesterified cyclodextrins as potential Artemisinin nanocarriers. II: In vitro behavior toward the immune system and in vivo biodistribution assessment of unloaded nanoparticles [Full paper ]

    J. B.G. Yaméogo, A. Gèze, L. Choisnard, J-L Putaux, R. Mazet, C. Passirani, M. Keramidas, J-L Coll, N. Lautram, J. Bejaud, R. Semdé, D. Wouessidjewe

    European Journal of pharmaceutics and biopharmaceutics, 88, 683-694

  • Article • Design of hyaluronan-based dopant for conductive and resorbable PEDOT ink [Full paper ]

    M. Leprince, P. Mailley, L. Choisnard, R. Auzély-Velty, I. Texier

    Carbohydr. Polym. 2023, 301

  • Article • Toward non-factor therapy in hemophilia: an antithrombin insensitive Gla-domainless factor Xa as tissue factor pathway inhibitor bait [Full paper ]

    M.-C. Dagher, A. Ersayin, L. Seyve, M. Castellan, C. Moreau, L. Choisnard, N. Thielens, R. Marlu, B. Polack, A. Thomas

    Res. Practice Thrombosis Haemostasis 2023, 7, 102175

  • Article • Crystal and molecular structure of V-amylose complexed with butan-1-ol [Full paper ]

    C. A. K. Le, K. Mazeau, Y. Nishiyama, Y. Ogawa, L. Choisnard, D. Wouessidjewe,

    Polymer, 2022, 243, 12451

  • Article • Topological defects in polycrystalline hexosomes from β-cyclodextrin fatty esters [Full paper ]

    Putaux, J. L. Lancelon-Pin, C. Choisnard, L. Gèze, A. Wouessidjewe, D.

    Soft Matter, 2022, 18, 2028-2038

  • Article • Helical Inclusion Complexes of Amylose with Aromatic Compounds: Crystallographic Evidence for New V-type Allomorphs [Full paper ]

    Le, C. A. K. Ogawa, Y. Grimaud, F. Nishiyama, Y. Morfin, I. Potocki-Veronese, G. Choisnard, L. Wouessidjewe, D. Putaux, J. L.

    Crystal Growth & Design 2022

  • Article • Optimizing chitin depolymerization by lysozyme to long-chain oligosaccharides [Full paper ]

    A. Masselin, A. Rousseau, S. Pradeau, L. Fort, R. Gueret, L. Buon, S. Armand, S. Cottaz, L. Choisnard, S. Fort

    Mar. Drugs 2021, 19, 320

  • Article • Comparison of three automated compounding devices for parenteral nutrition according to four key technical tests [Full paper ]

    Julien Leenhardt; Marjorie Durand; Luc Choisnard; Marie-Dominique Desruet; Roseline Mazet; Pierrick Bedouch

    European Journal of Hospital Pharmacy, 2021, 0, 1-6

  • Article • Pharmacokinetic study of intravenously administered artemisinin-loaded surface-decorated amphiphilic γ-cyclodextrin nanoparticles [Full paper ]

    J. Boumbéwendin Gérard Yaméogo, R. Mazet, D. Wouessidjewe, L. Choisnard, D. Godin-Ribuot, J.-L. Putaux, R. Semdé, A. Gèze

    Mat. Sci. Engin. C 2020, 106, 110281

  • Article • Recent Advances in the Design of Topical Ophthalmic Delivery Systems in the Treatment of Ocular Surface Inflammation and Their Biopharmaceutical Evaluation 

    Mazet, R. Yameogo, J. B. G. Wouessidjewe, D. Choisnard, L. Geze, A.

    Pharmaceutics, 2020, 12 (6), 570

  • Article • Capillary electrophoretic apparatus for the endpoint detection in microtitration methods [Full paper ]

    F. Oukacine, L. Choisnard, A. Gèze, E. Peyrin

    J. Chromatogr. A, 2019

  • Article • Single Crystals of V-Amylose Complexed with Bicyclic Organic Compounds. Special Issue: Polymer‐Solvent Complexes and Intercalates  [Full paper ]

    Cong‐Anh‐Khanh Le Luc Choisnard Denis Wouessidjewe Jean‐Luc Putaux


  • Article • Urinary trans-anti-7,8,9,10-tetrahydroxy-7,8,9,10-tetrahydrobenzo(a) pyrene as the most relevant biomarker for assessing carcinogenic polycyclic aromatic hydrocarbons exposure [Full paper ]

    Damien Barbeau, Simon Lutier, Luc Choisnard, Marie Marques, Renaud Persoons, Anne Maitre

    Environment International, 2018, 112, 147–155

  • Article • Inline coupling of electrokinetic preconcentration method to Taylor dispersion analysis for size-based characterization of low-UV-absorbing nanoparticles [Full paper ]

    F. Oukacine, A. Gèze, L. Choisnard, JL. Putaux, JP. Stahl, E. Peyrin

    Anal. Chem. 2018, 90, 2493–2500

  • Article • Polymorphism of crystalline complexes of V-amylose with fatty acids [Full paper ]

    Cong-Anh-Khanh Le, Luc Choisnard, Denis Wouessidjewe, Jean-Luc Putaux

    International Journal of Biological Macromolecules 2018,119, 555-564

  • Oral Comm • Le nettoyeur à vapeur a-t-il une place dans la prise en charge des dispositifs médicaux réutilisables à corps creux en stérilisation? 

    A. Bros, R. Mazet, L. Choisnard, N. Sylvoz, P. Bedouch, C. Guimier-Pingault

  • Article • The water test could be a good indication to evaluate the effectiveness of the sterile barrier system of rigid sterilization containers. [Full paper ]

    L. Decarout, C. Lambert, L. Choisnard, C. Andonian, C. Fayard

    Annales Pharmaceutiques Françaises, 2018, 76(6), 464-472

  • Article • Colorimetric nanosensor based on a selective target-responsive aptamer kissing complex [Full paper ]

    E. Goux, E. Dausse, V. Guieu, L. Azéma, G. Durand, M. Henry, L. Choisnard, J-J. Toulmé, C. Ravelet, E. Peyrin

    Nanoscale, 2017, 9, 4048 - 4052.

  • Book • Validation de la robustesse d'une méthode analytique par plan d'experiences 

    Morgan Germa, Luc Choisnard

    2015 • 1-4, - Paris

  • Article • Bioesterified polysubstituted-cycloedxtrin/surfactant nanoparticles obtained by multilevel self-assembly 

    L.Zerkoune, A. Angelova, L. Choisnard, A. Gèze, D. Wouessidjewe, S. Lesieur

    ICOMF14 Proceedings, MATEC Web of conferences, 2013, 4, 05001

  • Article • Self-assembled biotransesterified cyclodextrins as artemisinin nanocarriers - I : Formulation, lyoavailability and in vitro antimalarial activity assessment 

    Josias B.G. Yameogo, c, Annabelle Geze, , Luc Choisnard, Jean-Luc Putaux, Adama Gansane, Sodiomon B. Sirimad, Rasmane Semde, Denis Wouessidjewe

    Eur. J. Pharm. Biopharm, 2012, 80(3), 508-517.

  • Article • Physicochemical Characterization of of a-, β-, and γ-Cyclodextrins Bioesterified with Decanoate Chains Used As Building Blocks of Colloidal Nanoparticles 

    L. Choisnard, A. Gèze, C. Vanhaverbeke, J. B. G. Yamogo, J.-L. Putaux, B. Brasme, L. Jullien, S. Boullanger, C. Elfakir, D. Wouessidjewe

    Biomacromolecules, 2011, 12(8), 3031-3038.

  • Article • Forming Spirocyclohexadienone-oxocarbenium cation species in the biomimetic synthesis of amomols. 

    M. Traore, M. Maynadier, F. Souard, L. Choisnard, H. Vial, Y.-S. Wong

    J. Org. Chem. 2011, 76, 1409-1417.

  • Article • Colloidal systems made of biotransesterified alpha, beta, and gamma cyclodextrins grafted with C10 alkyl chains 

    A. Geze, L. Choisnard, J-L. Putaux, D. Wouessidjewe

    Materials science and engineering, 2009 ,C29,458-462

  • Article • Antimitotic and antiproliferative activities of chalcones: Forward structure-activity relationship 

    A. Boumendjel, E. Nicolle, P.-A. Carrupt, J. Boccard, M. Blanc, A. Geze, L. Choisnard, D. Wouessidgewe, C. Dumontet

    J. Med. Chem. 2008, 51, 2307-2310.

  • Article • Characterisation of complex amphiphilic cyclodextrin mixtures by high-performance liquid chromatography and mass spectrometry. 

    F. Kieken, C. West, K. Keddadouche, C. Elfakir, L. Choisnard, A. Gèze, D. Wouessidjewe

    J. Chrom. A, 2008, 1189, 385-391.

  • Article • Poudres, granulés et comprimés dans Pharmacie Galénique : Formulation et technologie Pharmaceutique 

    V. Busignies, D. Chulia, L. Choisnard, R. de Challemaison, A. Geze, S. Stainmesse, J. Siepmann, P. Tchoreloff, M. Viana, P. Wehrlé, D. Wouessidjewe,

    Editions Maloine 2007, Chapitre 2, 1-45.

  • Article • Formes galéniques en développement dans Pharmacie Galénique : Formulation et technologie Pharmaceutique 

    S. Begu, A. Bochot, L. Choisnard, P. Couvreur, D. Duchene, F. Edwards, E. Fattal, A. Geze, G. Ponchel, V. Preat, C. Tourne-Petaeille, D. Wouessidjewe

    Editions Maloine. 2007, Chapitre 8, 1-36.

  • Article • Miscellaneous nanoaggregates made of beta-CD esters synthesised by an enzymatic pathway 

    L. Choisnard, A. Geze, B.G.J. Yaméogo, J-L. Putaux, D. Wouessidjewe

    Int. J. Pharm. 2007, 344, 26-32.

  • Article • Biodistribution of intravenously administered amphiphilic beta-cyclodxetrin nanospheres 

    A. Geze, L. Tieu Chau, L. Choisnard, J.-P. Mathieu, D. Marti-Batlle, L. Riou, J.-P. Putaux, D. Wouessidjewe

    Int. J. Pharm. 2007, 344, 135-142.

  • Book • Pharmacie Galénique : Formulation et technologie Pharmaceutique 

    poudres, granulés et comprimés dans Pharmacie Galénique

    V. Busignies, D. Chulia, L. Choisnard, R. de Challemaison, A. Gèze, S. Stainmesse, J. Siepmann, P. Tchoreloff, M. Viana, P. Wehrlé, D. Wouessidjewe

    2007 • 1-44, Maloine - Paris

  • Book • Pharmacie Galenique : Formulation et technologie pharmaceutique 

    Formes galéniques en développement dans Pharmacie Galénique

    S. Begu, A. Bochot, L. Choisnard, P. Couvreur, D. Duchene, F. Edwards, E. Fattal, A. Geze, G. Ponchel, V. Preat, C. Tourné-Peteilh, D. Wouessidjewe

    2007 • 250-289, Maloine - Paris

  • Article • Nanoparticles of b-cyclodextrin esters obtained by self-assembling of biotransesterified b-cyclodextrin 

    L. Choisnard, A. Geze, J.L. Putaux, Y.S. Wong, D. Wouessidjewe

    Biomacromolecules 2006, 7, 515-520.

  • Article • Experimental design optimization for screening relvant free phenolic acids from various preparations used in Burkina Faso folk medicine 

    M. Kienbrebego, L. Choisnard, C. E. Lamien, A. Meda, D. Wouessidjewe, O. Nacoulma

    Afr. J. Trad. Comp. Alt. Med. 2006, 3, 115-128.

  • Article • Efficient size control of amphiphilic cyclodextrin nanoparticles through a statistical mixture design methodology. 

    L. Choisnard, A. Geze, M. Bigan, J. L. Putaux, D. Wouessidjewe

    J. Pharm. Pharmaceut. Sci. 2005, 8, 593-600

  • Article • Optimization of the preparation of aqueous suspensions of waxy maize starch nanocrystals using a response surface methodology. 

    H. Angellier, L. Choisnard, S. Molina-Boisseau, P. Ozil, A. Dufresne

    Biomacromolecules 2004, 5, 1545-1551.

  • Article • Long term stability study of amphiphilic b-cyclodextrin nanosphere suspensions monitored by dynamic light scattering and cryo-transmission electron microscopy 

    A. Gèze, J.-L. Putaux, L. Choisnard, P. Jéhan, D. Wouessidjewe

    J. Microencapsul. 2004, 21, 607-613.

  • Article • Application of the method of the experimental design to the study of a processing of unshrinkableness of wool fibers 

    L. Choisnard, M. Bigan, D. Blondeau, P. Dhulster, B. Leman, D. Guillochon

    J. Applied Polym. Sci. 2003, 89, 535-547.

  • Article • Kinetic study of the appearance of an antibacterial peptide in the course of bovine haemoglobin peptic hydrolysis 

    L. Choisnard, R. Froidevaux, B. Lignot, N. Nedjar-Arroume, D. Vercaigne-Marko, F. Krier, P. Dhulster, D. Guillochon

    Biotechnol. Appl. Biochem. 2002, 36, 187-194.

  • Article • Advancement in intermediate opioid peptide production in an enzymatic membrane reactor assisted by solvent extraction 

    P. Dhulster, R. Kapel, R. Froidevaux, N. Nedjar-arroume, A. Fertin-Bazus, L. Choisnard, D. Guillochon

    Desalination 2002, 148, 221-226.