Ahcène BOUMENDJEL

Parcours et intérêts

Ahcène BOUMENDJEL is a Professor of medicinal chemistry at the Pharmacy school of the University Grenoble Alpes. He is the head of the medicinal chemistry team and the director of the DPM. His research field lies on the chemistry of natural products with a special focus on the phytochemistry, design, synthesis and development of drug candidates. Professor BOUMENDJEL received his PhD in organic chemistry in 1991 from the University of Reims (France) under the supervision of Dr. Georges MASSIOT. After a 3 years postdoctoral fellow at the National Institutes of Health (NIH, Bethesda, USA) he spent two years working for a Biotech company in Boston (USA). In 1996, he was appointed as a Professor assistant in pharmacognosy at the Faculty of Pharmacy of Grenoble Alpes Univeristy and in 2008, he was promoted as a full Professor of medicinal chemistry.

Publications

• Article • Biodriven investigation of the wild edible mushroom Pleurotus eryngii revealing unique properties as functional food [Full paper ]

  S. Teniou, A. Bensegueni, B.M. Hybertson, B. Gao, S.K. Bose, J.M. McCord, B. Chovelon, C. Bensouici, A. Boumendjel, I. Hininger-Favier

  J. Funct. Foods., 2022, 89, 104965

• Article • Exploring the Structure-Activity Relationship of Benzylidene-2,3-Dihydro-1H-Inden-1-One Compared to Benzofuran-3(2H)-One Derivatives as Inhibitors of Tau Amyloid Fibers [Full paper ]

  Emeline Boukherrouba, Camille Larosa, Kim-Anh Nguyen, Jérémy Caburet, Laurent Lunven, Hugues Bonnet, Antoine Fortuné, Ahcène Boumendjel, Benjamin Boucherle, Sabine Chierici, Marine Peuchmaur

  Eur. J. Med. Chem. 2022, 231, 114139

• Article • Ditopic Chelators of Dicopper Centers for Enhanced Tyrosinases Inhibition [Full paper ]

  E. Buitrago, C. Faure, L. Challali, E. Bergantino, A. Boumendjel, L. Bubacco, M. Carotti, R. Hardré, M. Maresca, C. Philouze, H. Jamet, M. Réglier, C. Belle

  Chem. Eur. J. 2021, 27, 43844393

• Article • Chromones bearing amino acid residues: Easily accessible and potent inhibitors of the breast cancer resistance protein ABCG2 [Full paper ]

  E. Roussel, A. Moréno, N. Altounian, C. Philouze, B. Pérès, A. Thomas, O. Renaudet, P. Falson, A. Boumendjel

  Eur. J. Med. Chem. 2020, 202, 112503

• Article • Pyrrolizidine-Derived Alkaloids: Highly Toxic Components in the Seeds of Crotalaria Cleomifolia Used in Popular Beverages in Madagascar [Full paper ]

  A. H. D. Solofomalala, C. F. Rajemiarimoelisoa, R. L. Judicael, H. R. Randrianarivo, D. A. D. Rakoto, V. L. Jeannoda, A. Boumendjel

  Molecules 2021, 26, 3464

• Patent • Inhibiteurs selectifs du transporteur bcrp/abcg2 utilises comme agents pour abolir la résistance aux anticancéreux 

  A. Boumendjel, P. Falson, A. Moreno, B. Peres, E. Roussel

  2019 • 

• Article • Glycosyl-Substituted Dicarboxylates as Detergents for the Extraction, Overstabilization, and Crystallization of Membrane Proteins [Full paper ]

  K.-A. Nguyen, M. Peuchmaur, S. Magnard, R. Haudecoeur, C. Boyère, S. Mounien, I. Benammar, V. Zampieri, S. Igonet, V. Chaptal, A. Jawhari, A. Boumendjel, P. Falson

  Angew. Chem. Int. Ed. Engl. 2018, 57, 2948-2952.

• Article • Make Azoles Active Again: Chalcones as Potent Reversal Agents of Transporters-Mediated Resistance in Candida albicans. 

  S. Nim, P. Baghel, V.-K. Tran-Nguyen, B. Peres, K.-A. Nguyen, A. Di Pietro, P. Falson, R. Prasad, A. Boumendjel

  Future Med. Chem. 2018, 10, 2177-2186.

• Article • MRP1-dependent collateral sensitivity via cellular GSH depletion: identifying selective modulators and investigating their interest in MRP1-overexpressing multidrug-resistant cancer cells by comparison with other modulators. [Full paper ]

  D. Lorendeau, L. Dury, R. Nasr, A. Boumendjel, E. Teodori, M. Gütschow, P. Falson, A. Di Pietro, H. Cortay

  Curr. Med. Chem. 2017, 24, 1186-1213.

• Article • Modulators of the Efflux Pump Cdr1p of Candida albicans: Mechanisms of Action and Chemical Features. [Full paper ]

  V. K. Tran-Nguyen, R. Prasad, P. Falson, A. Boumendjel

  Curr. Med. Chem. 2017, 24, 3242-3253.

• Patent • Clamps moléculaires d’extraction et stabilisation en solution des protéines membranaires. 

  K. A. Nguyen, S. Magnard, M. Peuchmaur, J. Dauvergne, A. Boumendjel, P. Falson

  2017 • 

• Oral Comm • Du crible phénotypique à l’optimisation de hit : cas du MBL II 141, un inhibiteur puissant et sélectif de la protéine BCRP 

  A. Boumendjel

• Article • Traditional uses, phytochemistry and pharmacological properties of African Nauclea species: A review [Full paper ]

  R. Haudecoeur, M. Peuchmaur, B. Pérès, M. Rome, G. Sotoing Taiwe, A. Boumendjel, B. Boucherle

  Journal of Ethnopharmacology, 2018, 212, 106-136

• Article • Occurrences, biosynthesis and properties of aurones as high-end evolutionary products. [Full paper ]

  B. Boucherle, M. Peuchmaur, A. Boumendjel, R. Haudecoeur.

  Phytochemistry, 2017, 142, 92-111.

• Article • Human Tyrosinase and related proteins, are they new targets to fight melanoma? 

  E. Buitrago, R. Hardre, R. Haudecoeur, H. Jamet, C. Belle, A. Boumedjel, M. Reglier

  Curr. Top. Med. Chem. 2016, 3033-3047.

• Article • Chemical composition of the pods of Albizia polyphylla [Full paper ]

  Rajemiarimoelisoa C. F., Boyère C., Pellissier L., Peuchmaur M., Randrianarivo H. R., Doll Rakoto D. A., Jeannoda V. L., Boumendjel A.

  Nat. Prod. Res. 2016, 30, 1557-1560.

• Article • New Pseudodimeric Aurones as Palm Pocket Inhibitors of Hepatitis C Virus RNA-dependent RNA Polymerase [Full paper ]

  Amel Meguellati, Abdelhakim Ahmed-Belkacem, Alessandra Nurisso, Wei Yi, Rozenn Brillet, Nawel Berqouch, Laura Chavoutier, Antoine Fortuné, Jean-Michel Pawlotsky, Ahcène Boumendjel, Marine Peuchmaur

  Eur. J. Med. Chem. 2016, 115, 217-229

• Article • Nauclea latifolia: biological activities and alkaloid phyto-chemistry of a West African tree 

  B. Boucherle, R. Haudecoeur, E. Ferreira Queiroz, M. De Waard, J.-L. Wolfender, R. J. Robins, A. Boumendjel

  Nat. Prod. Rep. 2016, 33, 1034-1043

• Article • A retro-biosynthetic approach to the prediction of biosynthetic pathways from position-specific isotope analysis as shown for tramadol. [Full paper ]

  Romek KM, Nun P, Remaud GS, Silvestre V, Taïwe GS, Lecerf-Schmidt F, Boumendjel A, De Waard M, Robins RJ.

  Proc. Natl. Acad. Sci. U. S. A. 2015, 112, 8296-301.

• Article • Biomimetic Synthesis of Tramadol [Full paper ]

  F. Lecerf-Schmidt, R. Haudecoeur, B. Peres, M. M. Ferreira Queiroz, L. Marcourt, S. Challal, E. Ferreira Queiroz, G. Sotoing Taiwe, T. Lomberget, M. Le Borgne, J.-L. Wolfender, M. De Waard, R. J. Robins and A. Boumendjel

  Chem. Commun. 2015, 15, 14451-14453.

• Article • Design, Synthesis and Biological Evaluation of Novel Ring-Opened Cromakalim Analogues with Relaxant Effects on Vascular and Respiratory Smooth Muscles and as Stimulators of Elastin Synthesis 

  M. BOUHEDJA, B. PERES, W. FHAYLI, Z. GHANDOUR, A. BOUMENDJEL, G. FAURY, S. KHELILI

  Eur. J. Med. Chem. 2018, 144, 774-796.

• Article • High-content imaging assay to evaluate toxoplasma gondii invasion and proliferation: a multiparametric assay to screen new compounds 

  B. Touquet, L. Pellissier, P. Cavailles, W. Yi, V. Bellini, C. Mercier, M.-F. Delauw, A. Boumendjel, D. Aldebert.

  PlosOne, 2018, accepté

• Article • Arylthiosemicarbazones as antileishmanial agents [Full paper ]

  J. I. Manzano, F. Cochet, B. Boucherle, V. Gómez-Pérez, A. Boumendjel, F. Gamarro, M. Peuchmaur

  Eur. J. Med. Chem. 2016, 123, 161-170.

• Article • A novel platinum-maurocalcine conjugate induces apoptosis of human glioblastoma cells by acting through the ROS-ERK/AKT-p53 Pathway. 

  Aroui S, Dardevet L, W. BAjmia, M. de Boisvilliers, F. Perrin, A. Laajimi, A. Boumendjel, A. Kenani, J. M. Muller, M. de Waard.

  Mol Pharm. 2015, 12, 4336-4348.

• Article • 2-Indolylmethylenebenzofuranones as first effective inhibitors of ABCC2 [Full paper ]

  E. Baiceanu, K.-A. Nguyen, L. Gonzalez-Lobato, F. Loghin, M. Le Borgne, A. Boumendjel, M. Peuchmaur, P. Falson

  Eur. J. Med. Chem, 2016, 122, 408-418

• Article • Characterization of Potent ABCG2 Inhibitor Derived from Chromone: From the Mechanism of Inhibition to Human Extracellular Vesicles for Drug Delivery  [Full paper ]

  G. Valdameri, D. H. Kita, J. de Paula Dutra, D. L. Gomes, A. K. Tonduru, T. Kronenberger, B. Gavinho, R. Izadora Volpato, M. Mazetto de Cravalho, B. Pérès, I. F. Zattoni, F. Gomes de Moraes Rego, G. Picheth, R. Aves de Freitas, A. Poso, S. V. Ambudkar

  Pharmaceutics 2023, 15, 1259

• Article • Inhibitors of ABCG2-mediated multidrug resistance: Lead generation through computer-aided drug design  [Full paper ]

  L. Goracci, A. Nurisso, E. Roussel, B. Pérès, V. Chaptal, P. Falson, C. Marminon, J. Jose, M. Le Borgne, A. Boumendjel

  Eur. J. Med. Chem. 2023, 248, 115070

• Article • Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter [Full paper ]

  V. Chaptal, V. Zampieri, Benjamin Wiseman, C. Orelle, Juliette Martin, K.A. Nguyen, A. Gobet, M. Di Cesare, S. Magnard, W. Javed, Jad, Eid, A. Kilburg, M. Peuchmaur, J. Marcoux, M. Monticelli, M. Hogbom, G. Schoehn, J.M. Jault, A.Boumendjel et al

  Sci. Adv., 2022, 8, eabg9215

• Article • Aurone derivatives as promising antibacterial agents against resistant Gram-positive pathogens [Full paper ]

  H. Olleik, S. Yahiaoui, B. Roulier, E. Courvoisier-Dezord, J. Perrier, B. Pérès, A. Hijazi, E. Baydoun, J. Raymond, A. Boumendjel, M. Maresca, R. Haudecoeur

  Eur. J. Med. Chem. 2019, 165, 133–141

• Article • Piperidinyl-Embeded Chalcones Possessing anti PI3Kδ Inhibitory Properties Exhibit Anti-atopic Properties in Preclinical Models 

  C. Dumontet, G.Beck, F. Gardebien, R. Haudecoeur, D. Mathé, E.-L. Matera, A. Tourette, E. Mattei, J. Esmenjaud, C. Boyere, A. Nurisso, M. Peuchmaur, B. Peres, G. Bouchaud, A. Magnan, G. Monneret and A. Boumendjeld

  Eur. J. Med. Chem. 2018, In Press

• Article • 2-Hydroxypyridine-N-oxide-Embedded Aurones as Potent Human Tyrosinase Inhibitors [Full paper ]

  R. Haudecoeur, M. Carotti, A. Gouron, M. Maresca, E. Buitrago, R. Hardré, E. Bergantino, H. Jamet, C. Belle, M. Réglier, L. Bubacco, A. Boumendjel

  ACS Med. Chem. Lett. 2017, 8, 55-60.

• Article • Recombinant tyrosinase from Polyporus arcularius: overproduction in Escherichia coli, characterization and use in a study of aurones as tyrosinase 

  E. Böhmová, M. Kotík, A. Křenková, P. Man, R. Haudecoeur, A. Boumendjel, R. Hardre, Y. Mekmouche, E. Courvoisier-Dezord, M. Réglier, L. Martínková

  J. Agric. Food Chem. 64, 2925-2931.

• Article • New, highly potent and non-toxic, chromone inhibitors of the human breast cancer resistance protein ABCG2 

  A. R. Andrade Pires, F. Lecerf-Schmidt, J. Pazzinato, G. Jabor Gozzi, E. Winter, G. Valdameri, A. Veale, A. Boumendjel, A. Di Pietro, B. Pérès

  Eur. J. Med. Chem. 2016, 122, 291-301.

• Article • Disruption of fibres from the AcPHF6 tau model by naturally occurring aurones and synthetic analogs 

  L. Lunven, H. Bonnet, S. Yahiaoui, L. Da Costa, M. Peuchmaur, A. Boumendjel, S. Chierici

  ACS Chem. Neurosci. 2016, 7, 995-1003.

• Article • IPP51, a novel microtubule inhibitor with in vivo antitumor activity against bladder carcinoma 

  V. Martel-Frachet, M. Keramidas, A. Nurisso, S. Debonis, C. Rome, J.-L. Coll, A. Boumendjel, D. Skoufias, X. Ronot

  Oncotarget

• Article • Quantitative evaluation of the combination between cytotoxic drug and efflux transporter inhibitors based on a tumour growth inhibition model 

  A. Sostelly, L. Payen, J. Guitton, A. Di Pietro, P. Falson, M. Honorat, A. Boumendjel, A. Geze, G. Freyer, M. Tod

  Fundamental & Clinical Pharmacology, 2014, 28, 161-9.

• Article • Bioguidage search of active compounds from Waltheria indica L. (Malvaceae) used for asthma and inflammation treatment in Burkina Faso. 

  F. Zongo, C. Ribuot, A.Boumendjel, I.Guissou

  Fundam Clin Pharmacol. 2014, 28, 323-330.

• Article • Nauclea latifolia Smith (Rubiaceae) exerts antinociceptive effects in neuropathic pain induced by chronic constriction injury of the sciatic nerve. [Full paper ]

  G. Sotoing Taïwe, E. Ngo Bum, E. Talla, T. Dimo, A. Dawe, V. Sinniger, B. Bonaz, A. Boumendjel and M. De Waard.

  J. Ethnopharmacol. 2014, 151, 445-451.

• Article • Achilles compounds inducing selective apoptosis of resistant cancer cells overexpressing multidrug ABC transporters: a new therapeutic strategy? 

  G. Szakacs, M. M. Gottesman, A. Boumendjel, R. Kachadourian, B. J. Day, L. Payen, H. Cortay & A. Di Pietro

  Chem. Rev, 2014, 114, 5753-74.

• Article • Investigation of the Binding-Site Homology of Mushroom and Bacterial Tyrosinases by Aurones as Effectors 

  R. Haudecoeur,A. Gouron,C. Dubois, H. Jamet, M. Lightbody, R. Hardré, A. Milet, E. Bergantino, L. Bubacco, C. Belle, M. Réglier, A. Boumendjel

  ChemBioChem, 2014, 15, 1325-33.

• Article • B-ring modified aurones as promising allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase. 

  A. Meguelatti, A. Ahmed-Belkacem, W. Yi, R. Haudecoeur, M. Crouillère, R. Brillet, J.-M. Pawlotsky, A. Boumendjel, M. Peuchmaur

  Eur. J. Med. Chem. 2014, 80, 579-592.

• Article • Collateral sensitivity of resistant MRP1 overexpressing cells to flavonoids and derivatives through GSH efflux 

  D. Lorendeau, E. Genoux-Bastide, L. Dury, F. Lecerf-Schmidt, R. Terreux, S. Magnard, A. Di Pietro, A. Boumendjel, H. Baubichon-Cortay

  Biochem. Pharmacol. 2014, 90, 235-45.

• Article • Exploring the interaction of N/S compounds with dicopper center: from model studies to tyrosinase inhibition. 

  E. Buitrago, A. Vuillamy, A. Boumendjel, W. Yi, G. Gellon, R. Hardré, G. Serratrice, M. Réglier, C. Belle

  J. Inorg. Chem. (acceptée)

• Article • MBL-II-141 enhances irinotecan anticancer efficiency in ABCG2 positive xenografts. 

  M. Honorat, J. Guitton, C. Gauthier, C. Bouard, R. Terreux, H. Gervot, C. Rioufol, A. Boumendjel, A. Puisieux, A. Di Pietro, L. Payen Lea

  Oncotarget, (acceptée)

• Article • A template model for studying anticancer drug efflux transporter inhibitors in vitro. 

  A. Sostelly, L. Payen, J. Guitton, A. Di Pietro, P. Falson, M. Honorat, G. Valdamieri, A. Geze, A. Boumendjel, G. Freyer, M. Tod

  Fundamental & Clinical Pharmacol. 2013, 27, 544-56.

• Article • Structure-Activity Relationships in the Development of Allosteric Hepatitis C Virus RNA-Dependent RNA Polymerase Inhibitors: Ten Years of Research [Full paper ]

  R. Haudecoeur, M. Peuchmaur, A. Ahmed-Belkacem, J.-M. Pawlotsky,A. Boumendjel

  Med. Res. Rev. 2013, 33, 934-984.

• Article • 3-Aryl-4-methyl-2-quinolones targeting multiresistant Staphylococcus aureus bacteria. 

  A. Doléans-Jordheim, J.-B. Veron, O. Fendrich, E. Bergeron, A. Montagut-Romans, Y.-S. Wong, B. Furdui, J. Freney, C. Dumontet, A. Boumendjel

  ChemMedChem, 2013, 8, 652-657.

• Article • Botany, traditional uses, phytochemistry and pharmacology of Waltheria indica L. (Syn. Waltheria americana. 

  F. Zongo,C. Ribuot, A. Boumendjel, I. Guissou

  J Ethnopharmacology, 148, 14-26.

• Article • Breast Cancer Resistance Protein (BCRP/ABCG2): discovery of potent and highly selective inhibitors. 

  F. Lecerf-Schmidt, B. Peres, G. Valdameri,L. Payen, A. Di Pietro, A. Boumendjel

  Future Med. Chem. 2013, 5, 1037-1045.

• Article • Occurrence of the synthetic analgesic tramadol in an african medicinal plant [Full paper ]

  A. Boumendjel, G. Sotoing Tawe, E. Ngo Bum, Tanguy Chabrol, C. Beney, V. Sinniger, R. Haudecoeur, L. Marcourt, S. Challal, E. Ferreira Queiroz, F. Souard, M. Le Borgne, T. Lomberget, A. Depaulis, C. Lavaud, R. Robins, J.-L. Wolfender, B. Bonaz, M. De Waar

  Angewandte Chemie Int. Ed. 2013, 52, 11780–11784.

• Article • Identification of novel specific reversal agents of the Leishmania LABCI4 transporter through screening and optimization of flavonoid and trolox derivatives. 

  J. Ignacio Manzano, F. Lecerf-Schmidt, M.-A. Lespinasse, A. Di Pietro, S. Castanys, A. Boumendjel, F. Gamarro

  Antimicrob Agents Chemotherapy. 2013, 57, 3719-3730.

• Article • AG11, a novel dichloroflavanone derivative with antimitotic activity towards human bladder cancer cells. 

  A. Juhem; A. Boumendjel, B. Touquet, A. Guillot, A. Popov, X. Ronot, V. Frachet

  Anticancer Research, 2013, 33, 4445-4452.

• Article • Structure-activity relationships of chromone derivatives toward mechanism of interaction with, and inhibition of, breast cancer resistance protein ABCG2 

  E. Winter, F. Lecerf-Schmidt, B. Peres, M. Lightbody, C. Gauthier, C. Ozvegy-Laczka, B. Sarkadi, T. Creczynski-Pasa, A. Boumendjel, A. Di Pietro.

  J. Med. Chem. 56, 9849-9860.

• Patent • Nouveaux dérivés de chalcone présentant une activité anti-allergique 

  A. Boumendjel, G. Monneret, C. Dumontet

  2013 • UJF, CNRS, Inserm, UCBL

• Patent • Extraction of tramadol from Nauclea Latifolia from Cameroon. 

  G. Sotoing Taïwe, A. Boumendjel, M. De Waard

  2013 • Inserm, UJF, CNRS

• Article • Versatile effects of aurone structure on the mushroom Tyrosinase activity 

  C. Dubois, R. Haudecoeur, M. Orio, C. Belle, C. Bochot, A. Boumendjel, R. Hardré, H. Jamet, M. Réglier

  ChemBioChem. 2012, 13, 559-565.

• Article • Substituted chromones as highly-potent nontoxic inhibitors, specific for the breast cancer resistance protein ABCG2. 

  G. Valdameri, E. Genoux-Bastide, B. Peres, R. Terreux, C. Gauthier, J. Guitton, S. M. B. Winnischofer, M. Rocha, A. Boumendjel, A. Di Pietro

  J. Med. Chem.2012, 55, 966–970.

• Article • A Synthetic chalcone derivative is a potent inducer of glutathione biosynthesis. 

  R. Kachadourian, B. J. Day, S. Pugazhenti, C. C. Franklin, E. Genoux-Bastide, G. Mahaffey, C. Gauthier, A. Di Pietro, A. Boumendjel

  J. Med. Chem. 2012, 55, 1382-8.

• Article • Investigation of chalcones as inhibitors of ABCG2: identification of structural frameworks required for both potent inhibition and selectivity. 

  C. Gauthier, G. Valdameri, R. Terreux, R. Kachadourian, B. J. Day, Sheila M. B. Winnischofer, M. E. M. Rocha, V. Frachet, X. Ronot, A. Di Pietro, A. Boumendjel.

  J. Med. Chem. 2012, 55, 3193-3200.

• Article • Recent Advances in the Medicinal Chemistry of Aurones 

  R. Haudecoeur, A. Boumendjel

  Curr. Med. Chem. 2012,19, 2861-2875.

• Article • 6-Halogenochromones bearing tryptamine: one step access, potent and highly selective inhibitors of breast cancer resistance protein. 

  G. Valdameri, E. Genoux-Bastide, C. Gauthier, R. Terreux, S. M. B. Winnischofer, M. E. M. Rocha, A. Di Pietro, A. Boumendjel

  ChemMedChem. 2012, 7, 1177-1180.

• Article • Chalcone JAI-51 improves efficacy of synchrotron microbeam radiation therapy of brain tumors 

  A. Bouchet, A. Boumendjel, E. Khalil, R. Serduc, E. Brauer, E. A. Siegbahn, G. Le Duc, J.- A. Laissue, Jean Boutonnat

  J. Synchrotron Radiat. 2012, 19, 478-482.

• Article • Identification of Xanthones as Selective Killers of Cancer Cells Overexpressing the ABC Protein, MRP1 

  E. Genoux-Bastide, D. Lorendeau, E. Nicolle,S. Yahiaoui,S. Magnard,A. Di Pietro,H. Baubichon-Cortay,A. Boumendjel

  ChemMedChem. 2011, 6, 1478-1484.

• Article • Discovery of the Naturally Occurring Aurones as Potent and non Toxic Allosteric Inhibitors of Hepatitis C Virus Polymerase(NS5B) 

  R. Haudecoeur, A. Ahmed-Belkacem, W. Yi, A. Fortune, R. Brillet, C. Belle, E. Nicolle, J.-M. Pawlotsky, A. Boumendjel

  J. Med. Chem. 2011, 54, 5395–5402.

• Article • Refinement of Arylthiosemicarbazone Pharmacophore in Inhibition of Mushroom Tyrosinase 

  W. Yi, C. Dubois, S. Yahiaoui, R. Haudecoeur, C. Belle, H. Song, R. Hardré, M. Réglier and A. Boumendjel

  Eur. J. Med. Chem. 2011, 46, 4330-4335.

• Article • A Straightforward conversion of Aurones to 2-Benzoylbenzofuranes: Transformation of One Class of Natural Products into Another 

  S. Yahiaoui, M. Peuchmaur, A. Boumendjel

  Tetrahedron, 2011, 67, 7703-7707

• Article • Structural requirement of arylindolylpropenones as anti-bladder carcinoma cells agents. 

  V. Martel-Frachet, M. Kadri, A. Boumendjel, X. Ronot.

  Bioorg. Med. Chem. 2011, 19, 6143-6148.

• Article • The acridone derivative MBLI-87 reverses breast cancer resistance protein-mediated resistance to irinotecan in xenografts. 

  O. Arnaud, A. Boumendjel, A. Geze, P. Falson, C. Dumontet, A. Di Pietro, L. Payen

  Eur. J. Cancer, 2011, 47, 640-648.

• Patent • Preparation of novel azacoumarin derivs. as MDR pump inhibitors useful as antimicrobial agents and as potentiators of the antimicrobial agents 

  A. Doleans-Jordheim, J. Freney, C. Dumontet, A. Boumendjel, J.-B. Veron, Y.-S. Wong

  2011 • UJF, CNRS, UCBL1, Hospices Civils de Lyon

• Article • The effect of flavonoid derivatives on doxorubicin-related formation of hydroxyl radicals. 

  P. Soucek, E. Kondrova, P. Stopka, A. Boumendjel, Y.-F. Ueng, I. Gut.

  Anti-Cancer Drugs, 2011, 22, 176-184.

• Article • The acridone derivative MBLI-87 reverses breast cancer resistance protein-mediated resistance to irinotecan in xenografts. 

  O. Arnaud, A. Boumendjel, A. Geze, P. Falson, C. Dumontet, A. Di Pietro, L. Payen

  E. J. Cancer, 2011, 47, 640-648.

• Article • Flavonoids as anticancer agents: Recent Progress and state of the art 

  E. Genoux, E. Nicolle, A. Boumendjel

  Curr. Org. Chem. 2011, 15, 2608-2615.

• Article • Targeting the multidrug resistance-conferring ABCG2 transporter with flavonoidic inhibitors: in vitro optimization and in vivo validation 

  A. Boumendjel, S. Macalou, G. Valdameri, A. Pozza, C. Gauthier, O. Arnaud, E. Nicolle, S. Magnard, P. Falson, R. Terreux, P.-A. Carrupt, L. Payen, A. Di Pietro

  Curr. Med. Chem. 2011, 18, 3387-3401.

• Article • Flavonoids as promising lead compounds in type 2 diabetes mellitus: molecules of interest and structure-activity relationship 

  E. Nicolle, F. Souard, P. Faure, A. Boumendjel

  Curr. Med. Chem. 2011,18, 2661-2672.

• Article • 1-Azaaurones derived from the naturally occurring aurons as potential antimalarial drugs. 

  F. Souard, S. Okombi, C. Beney, S. Chevalley, A. Valentin, A. Boumendjel.

  Bioorg. Med. Chem. 2010, 18, 5724-5731.

• Patent • Nouveaux dérives hétérocycliques, pour leur activité antivirale, en particulier pour le traitement du VHC 

  A. Boumendjel, R. Haudecoeur, H. Ahmed-Belkacem, J.-M. Pawlotsky, R. Brillet, C. Belle

  2010 • UJF, CNRS

• Article • 3D Solvatochromic analysis of molecular interaction forces between flavonoid derivatives and P glycoprotein mediated multidrug resistance 

  J. Boccard, E. Nicolle, A. Di Pietro, J. Boccard, S. Rudaz, A. Boumendjel, P.-A. Carrupt

  Eur. J. Pharm. Sci. 2009, 36, 254-264.

• Article • QSAR analysis and molecular modeling of ABCG2-specific inhibitors 

  A. Boumendjel, E. Nicolle, S. Macalou, E. Genoux, A. Ahmed-Belkacem, P.-A. Carrupt, A. Di Pietro.

  Adv. Drug. Deliver. Rev. 61, 34-46.

• Article • Chalcones derivatives acting as cell cycle blockers: Potential anticancer drugs 

  A. Boumendjel, X. Ronot, J. Boutonnat

  Curr. Drug. Targets, 2009, 10, 363-371.

• Article • Investigation of a new 1,3-diarylpropenone as a potential antimitotic agent targeting bladder carcinoma 

  V. Martel-Frachet, J. Areguian, M. Blanc, B. Touquet, A. Lamarca, X. Ronot, A.Boumendjel.

  Anti-Cancer Drugs

• Book • ABC Proteins and Multidrug Resistance 

  Reversal agents of multidrug resistance mediated by MRPS

  A. Boumendjel, A. Florin, J. Boutonnat

  2009 • 261-288, Wiley & Sons, Inc. - New Jersey, USA

• Book • ABC Proteins and Multidrug Resistance 

  Reversal agents for breast cancer resistance protein (BCRP)-mediated multidrug resistance

  J. Boutonnat, A. Florin, A. Boumendjel

  2009 • 289-313, Wiley & Sons, Inc. - New Jersey, USA

• Article • Breast Cancer Resistance Protein (BCRP, ABCG2): New Inhibitors and QSAR Studies by 3D Solvatochromic Analysis 

  E. Nicolle, J. Boccard, D. Guilet, M.-G. Dijoux-franca, E. Zelefac, S. Macalou, J. Schmidt, P.-A. Carript, A. Di Pietro, A. Boumendjel

  Eur. J. Pharm. Sci. 2009, 38, 39-46

• Article • A. Boumendjel, M. Blanc, G. Williamson, D. Barron. An efficient synthesis of flavanone glucuronides. 

  A. Boumendjel, M. Blanc, G. Williamson, D. Barron.

  J. Agric. Food Chem. 2009, 57, 7264-7267.

• Article • A new chalcone derivative as a potential agent for treatment of glioblastoma. 

  A. Boumendjel, A. Florin, P. Champelovier, V. Peyrot, D. Allegro, D. Muhammad, F. Souard, M. Derouazi, B. Toussaint, J. Boutonnat

  BMC Cancer, 2009, 9, 242-250.

• Article • Antimitotic and antiproliferative activities of chalcones: Forward structure-activity relationship 

  A. Boumendjel, E. Nicolle, P.-A. Carrupt, J. Boccard, M. Blanc, A. Geze, L. Choisnard, D. Wouessidgewe, C. Dumontet

  J. Med. Chem. 2008, 51, 2307-2310.

• Article • Flavonoids as RTK inhibitors and potential anticancer agents. 

  F. Teillet, A. Boumendjel, J. Boutonnat and X. Ronot

  Med. Res. Rev. 2008,28, 715-745

• Article • The effect of flavonoid derivatives on doxorubicin transport and metabolism 

  R. Václavíková, E. Kondrová, M. Ehrlichová, A. Boumendjel, J. Kovář, P. Stopka, P. Souček and I. Gut

  Bioorg. Med. Chem. 2008, 16, 2034-2042

• Article • Biotransformation of anthracene by Tetrahymena pyriformis and selected fungi and toxicity of the biotransformation products 

  P. Guiraud, J-L. Bonnet, A. Boumendjel, M. Kadri, M. Dusser, J. Bohatier and R. Steiman

  Ecotox. Environ. Safety, 2008, 69, 296-305

• Article • 2-Arylidenedihydroindole-3-ones: Design, synthesis, and biological activity on bladder carcinoma cell lines. 

  B. Gerby, A. Boumendjel, M. Blanc, P. P. Bringuier, P. Champelovier, A. Fortune, X. Ronot, J. Boutonnat.

  Bioorg. Med. Chem. Lett. 2007, 17, 208-213.

• Article • Use of p-hydroxycinnamic acid derivatives in cosmetic or dermatological compositions. 

  S.Okombi, D.Rival, A.Boumendjel, A-M.Mariotte, E. Perrier.

  Brit. UK Pat. Appl. 2007, 66pp. CODEN: BAXXDU GB 2431876 A 20070509

• Article • Preparation of new chalcone derivatives with antimitotic activity. 

  A.Boumendjel, Ch.Dumontet, M.Blanc, A-M.Mariotte.

  Fr. Demande 2007,33pp. CODEN: FRXXBL FR 2896245 A1 20070720

• Article • Acridone derivatives: design, synthesis, and inhibition of breast cancer resistance protein ABCG2. 

  A. Boumendjel, S. Macalou, H.Ahmed-Belkacem, M. Blanc, A. Di Pietro.

  Bioorg. Med. Chem. 2007, 15, 2892-2897.

• Article • Discovery of Benzylidenebenzofuran-3(2H)-one (Aurones) as Potent Inhibitors of Human Tyrosinase 

  S. Okombi, D. Rival, A.-M. Mariotte, E. Perrier, A. Boumendjel

  J. Med. Chem. 2006, 49, 329-333.

• Article • Inhibitors of cancer cell multidrug resistance mediated by Breast Cancer Resistance Protein (BCRP/ABCG2) 

  A. A. Belkacem, A. Pozza, S. Macalou, J. M. Perez-Victoria, A. Boumendjel, A. Di Pietro

  Anti-Cancer Drugs, 2006, 17, 239-244.

• Article • Analogues of N-cinnamoylphenalkylamides: potent inhibitors of human-melanocyte tyrosinase 

  S. Okombi, D. Rival, A-M. Mariotte, E. Perrier, A. Boumendjel

  Bioorg. Med. Chem. Lett. 2006, 16, 2252-2255.

• Article • Modulation of paclitaxel transport by flavonoide derivatives in human breast cancer cells. Is there a Correlation Between Binding Affinity to NBD of P-gp and Modulation of Transport? 

  R. Vaclavikova, A. Boumendjel, M. Ehrlichova, J. Kovar, I. Gut

  Bioorg. Med. Chem. 2006, 14, 4519-4525.

• Patent • Nouveaux dérivés de chalcones à activité antimitotique. 

  A. Boumendjel, M. Blanc, A.-M. Mariotte, C. Dumontet.

  2006 • Université Claude Bernard - Lyon I, Université Joseph Fourier - Grenoble I INSERM CNRS

• Book • La cytométrie en flux 

  Fluorochromes

  A. Boumendjel, D. Grunwald,E. Nicolle, X. Ronot

  2006 • 47-58, Lavoisier - Paris

• Article • Anticancer Multidrug Resistance Mediated by MRP1: Recent Advances in the Discovery of Reversal Agents 

  A. Boumendjel.; G. Conseil.; H. Baubichon-Cortay.; and A. Di Pietro

  Med. Res. Rev. 2005, 25, 453-472

• Article • A one-step synthesis of 2-alkyl-5-hydroxychromones and 3-alkoyl-2-alkyl-5-hydroxychromones 

  S. Okombi, J. Schmidt, A-M. Mariotte, E. Perrier, A. Boumendjel

  Chem. Pharm. Bull. 2005, 53, 1460-1462.

• Patent • Use of aurones for their activity in cosmetic or dermatological compositions 

  S. Okombi, D. Rival, A. Boumendjel, A.-M. Mariotte, E. Perrier

  2005 • Engelhard-Lyon - CNRS - Université de Grenoble I

• Article • 2’-Amino-a-chloroacetophenone as a valuable tool for the synthesis of conveniently substituted a,b-epoxychalcones derivatives. 

  M. Blanc.; M. Martin.; S. Okombi and A. Boumendjel

  Chem. Pharm. Bull. 2005, 53, 435-436.

• Article • Piperazinobenzopyranones and phenalkylaminobenzo- pyranones: potent inhibitors of breast cancer resistance protein (ABCG2). 

  A. Boumendjel.; E. Nicolle.; T. Moraux.; B. Gerby.; M. Blanc, X. Ronot and J. Boutonnat

  J. Med. Chem. 2005, 48, 7275-7281.

• Article • 2’-Amino-a-chloroacetophenone as a valuable tool for the synthesis of conveniently substituted a,b-epoxychalcones derivatives. Chem. Pharm. Bull. 2005, 53, 435-436. 

  M. Blanc.; M. Martin.; S. Okombi and A. Boumendjel.

  Chem. Pharm. Bull. 2005, 53, 435-436.

• Patent • Utilisation des dérivés de l’acide para-coumarique ou para-hydroxycinnamique dans des compositions cosmétiques ou dermatologiques 

  S. Okombi, D. Rival, A. Boumendjel, A-M. Mariotte, E. Perrier

  2005 • Engelhard Lyon - Université de Grenoble I - CNRS

• Article • Antimitotic activity of 5-hydroxy-7-methoxy-2-phenyl -4-quinolones 

  M. Hadjeri,E-L. Peiller, C. Beney, N. Deka,M. A. Lawson, C. Dumontet, A. Boumendjel.

  J. Med. Chem. 2004, 47, 4964-4970

• Article • A short and simple method for the synthesis of 4,6-dimethoxyazaaurones. 

  M. Lawson, A.-M. Mariotte, A. Boumendjel

  Heterocyclic Commun. 2003, 9, 149-152.

• Article • Recent Advances in the Synthesis of Conveniently Substituted Flavones, quinolones, chalcones and aurones: Potential biologically active molecules 

  M. Hadjeri, C. Beney, A.-M. Mariotte, A. Boumendjel

  Curr. Org. Chem. 2003, 7, 679-689.

• Article • Modulation of P-glycoprotein mediated multidrug resistance by flavonoid derivatives 

  M. Hadjeri, M. Barbier, X. Ronot, A.-M. Mariotte, A. Boumendjel, J. Boutonnat

  J. Med. Chem. 2003, 46, 2125-2131.

• Article • Aurones: A subclass of flavonoids with promising biological potential 

  A. Boumendjel

  Curr. Med. Chem. 2003, 10, 2621-2630

• Article • Hesperitin Esters: Highly Stable Flavanones With Both Free Radical Scavenging and Anti-Elastase Activities 

  A. Boumendjel.; D. Rival.; A-M. Mariotte and E. Perrier.

  Pharm. Biol. 2003, 41, 546-549

• Article • Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters. 

  A. Di Pietro, G. Conseil, J.-M. Pérez-Victoria, G. Dayan, H. Baubichon-Cortay, D. Trompier, J.-M. Jault, de Wet, G. Comte, A. Boumendjel, A.-M. Mariotte, C. Dumontet, D. B. McIntosh, Goffeau, S. Castanys, F. Gamarro, D. Barron.

  Cell. Mol. Life Sci. 2002, 59, 307-322.

• Article • Acetylated dimethoxyaniline as a key intermediate for the synthesis of aminoflavones and quinolones. 

  N. Deka, M. Hadjeri, M. A. Lawson, C. Beney, A.-M. Mariotte, A. Boumendjel

  Heterocycles 2002, 57, 123-128.

• Article • 4-Hydroxy-6-methoxyaurones with high-affinity binding to cytosolic domain of P-glycoprotein 

  A. Boumendjel, C. Beney, N. Deka, M. A. Lawson, D. Trompier, H. Baubichon-Cortay, A. Di Pietro

  Chem. Pharm. Bull. 2002, 50, 854-856

• Article • Recent advances in the discovery of flavonoids and analogs with high-affinity binding to P-glycoprotein responsible for cancer cell multidrug resistance. 

  A. Boumendjel, A. Di Pietro, C. Dumontet, D. Barron

  Med. Chem. Rev. 2002, 22, 512-529

• Article • Deacetylation of activated acetophenones with tin(IV) chloride. 

  M. Hadjeri, A.-M. Mariotte, A. Boumendjel

  J. Chem. Res. 2002, 463-464

• Article • An efficient synthesis of 4,6-dimethoxyaurones 

  C. Beney, A.-M. Mariotte, A. Boumendjel

  Heterocycles 2001, 55, 967-972.

• Article • B-Ring substituted 5,7-dihydroxyflavonols with high-affinity binding to P-glycoprotein responsible for cell multidrug resistance 

  A. Boumendjel, F. Bois, C. Beney, A.M. Mariotte, G. Conseil, A. Di Pietro

  Bioorg. Med. Chem. Lett. 2001, 11, 75-77.

• Article • Elaboration of new monoterpenoid indole alkaloids containing a dihydrofuran unit 

  A. Boumendjel, J.M. Nuzillard, G. Massiot

  Synlett 2001, 7, 1125-1126

• Article • Interaction of polyphenolic natural products and synthetic derivatives with P-glycoprotein, a transporter involved in multidrug resistance (MDR): A state of the art. 

  D. Barron, A. Boumendjel, A. Di Pietro, C. Dumontet, D. Mc Intosh

  Anticancer Res. 2001, 21, 1580-1581.

• Article • Alkylation of 2-phenyl-4-quinolones : synthetic and structural studies. 

  M. Hadjeri, A.-M. Mariotte, A. Boumendjel

  Chem. Pharm. Bull. 2001, 49, 1352-1355.

• Article • Microwave mediated solvent-free acetylation of deactivated and hindered phenols 

  N. Deka, A.-M. Mariotte, A. Boumendjel

  Green Chem. 2001, 3, 263-264

• Patent • Flavonoid compounds and their use, especially in cosmetics 

  D. Rival, A. Boumendjel, A.-M. Mariotte, E. Perrier

  1999 • Université de Grenoble I