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Le DPM
Les Equipements
L'Environnement
Zoom sur... Le Bâtiment André Rassat
Nommé d'après une figure tutélaire de la chimie grenobloise, ce bâtiment est recouvert d’une double peau en feuille métallique qui apporte une protection thermique sur 3 côtés et crée une unité architecturale favorisant l'intégration parmi les arbres du site. -
Thématiques
Le Thème
« Approches thérapeutiques innovantes »De nouvelles solutions thérapeutiques, de la cible biomacromolécu-laire émergente aux approches originales pour traiter les maladiesLe Thème
« Nouveaux systèmes de vectorisation »Combiner les propriétés d’inclusion de principes actifs, de franchisse-ment de barrières, d’adressage et de relar-gage en milieu vivantLe Thème
« Outils de bio-détection et bio-quantification »Des dispositifs analytiques originaux pour la détection de cibles, de l’ion au micro-organisme en milieu complexeZoom sur... La Chémobiologie
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Équipes
L'Équipe « COMET »
« COMET » développe la conception rationnelle, la synthèse et/ou l'extraction de composés à forte diversité/complexité comme nouveaux agents thérapeutiques et outils moléculaires pour la pénétration cellulaire ou la détection de biomolécules, actifs in vivo.L'Équipe « NOVA »
« NOVA » utilise des acides nucléiques fonctionnels comme éléments de reconnaissance pour des applications thérapeutiques ou diagnostiques, comme la sélection d'oligonucléotides, ou le développement de dispositifs d'analyses et de nanovecteurs.Les Services
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Productions
Les Publications
La Vulgarisation
Les JSM
Zoom sur... La 12ème JSM (15 juin 2023)
Le DPM organise des journées scientifiques consacrées au médicament. L'objectif est de rassembler les spécialistes académiques et industriels autour d'une thématique. 2023 : Apports de la Chimie Click et de la Lumière en Chemobiologie -
Partenariats
Les Formations
Les Consortiums
Les Financements
Zoom sur... L'environnement Grenoblois
Le DPM est un acteur central sur le bassin grenoblois en chimie, biologie et santé, lié au CHU Grenoble Alpes et à de nombreuses autres organisations : Pole de Recherche CBS, ICMG, Labex ARCANE, EUR CBH, Institut Carnot Polynat, Réseau GREEN.
Denis WOUESSIDJEWE
Professeur émérite au DPM depuis le 01-09-1999
Bureau : E206
rf@.@sepla-elbonerg-vinu@@@isseuow@.@sined@
☏ 04 76 63 53 02
Publications
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Article • Polymorphism of V-Amylose Cocrystallized with Aliphatic Diols [Full paper ]
C. Anh Khanh Le, L. Choisnard, D. Wouessidjewe, J.-L. Putaux
Polymer 2021, 213, 123302
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Article • Crystal and Molecular Structure of V-Amylose Complexed with Ibuprofen [Full paper ]
C. Anh Khanh Le, Y. Ogawa, F. Dubreuil, F. Grimaud, K. Mazeau, G. R. Ziegler, S. Tanwar, Y. Nishiyama, G. Potocki-Veronese, L. Choisnard, D. Wouessidjewe, J.-L. Putaux
Carbohydr. Polym. 2021, 261, 117885
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Article • Biopharmaceutical Assessment of Dexamethasone Acetate-Based Hydrogels Combining Hydroxypropyl Cyclodextrins and Polysaccharides for Ocular Delivery [Full paper ]
azet, R. Garcia-Otero, X. Choisnard, L. Wouessidjewe, D. Verdoot, V. Bossard, F. Diaz-Tome, V. Blanc-Marquis, V. Otero-Espinar, F. J. Fernandez-Ferreiro, A. Geze, A.
Pharmaceutics 2020, 12 (8), 717
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Article • Biodistribution and preliminary toxicity studies of nanoparticles made of Biotransesterified β–cyclodextrins and PEGylated phospholipids [Full paper ]
P. Perret, S. Bacot, A. Gèze, A. Gentil Dit Maurin, M. Debiossat, A. Soubies, V. Blanc-Marquis, L. Choisnard, J. Boutonnat, C. Ghezzi, J.L. Putaux, C. Lancelon-Pin, L.M. Riou,⁎, D. Wouessidjewe
Materials Science & Engineering C 2018, 85, 7-17
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Article • Investigation of Combined Cyclodextrin and Hydrogel Formulation for Ocular Delivery of Dexamethasone Acetate by Means of Experimental Designs
Roseline Mazet , Luc Choisnard , Delphine Levilly , Denis Wouessidjewe and Annabelle Gèze
Pharmaceutics, 2018 , 10 , 249
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Article • Self-assembly of amphiphilic biotransesterified B-cyclodextrins : supramolecular structure of nanoparticles and surface properties [Full paper ]
Jean-Luc Putaux, Christine Lancelon-Pin, François-Xavier Legrand, Marion Pastrello, Luc Choisnard, Annabelle Gèze, Cyrille Rochas and Denis Wouessidjewe
Langmuir 2017, 33, 7917–7928
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Article • New nanoparticles obtained by co-assembly of amphiphilic cyclodextrins and nonlamellar single-chain lipids: Preparation and characterization [Full paper ]
Nguyen, C-H ; Putaux, J-L; Santoni, G; Tfaili, S; Fourmentin, S; Coty, J-B; Choisnard, L; Geze, A; Wouessidjewe, D; Barratt, G; Lesieur, S; Legrand, F-X
Int. J. Pharm. 2017, 531(2), 444-456
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Article • Biocompatible Double-Membrane Hydrogels from Cationic Cellulose Nanocrystals and Anionic Alginate as Complexing Drugs Codelivery [Full paper ]
Ning Lin, Annabelle Gèze, Denis Wouessidjewe, Jin Huang, and Alain Dufresne
ACS Applied Materials & Interfaces 2016, 8(11), 6880-6889
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Article • Mesoporous self-assembled nanoparticles of biotransesterified cyclodextrins and nonlamellar lipids as carriers of water-insoluble substances [Full paper ]
Zerkoune, Leila; Lesieur, Sylviane; Putaux, Jean-Luc; Choisnard, Luc; Geze, Annabelle; Wouessidjewe, Denis; Angelov, Borislav; Vebert-Nardin, Corinne; Doutch, James; Angelova, Angelina
Soft Matter, 2016, 12, 7539-7550
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Article • Progress in developing amphiphilic cyclodextrin-based nanodevices for drug delivery
J. Yameogo, A. Geze, L. Choisnard, J-L. Putaux, S. Semde, D. Wouessidjewe
Current Topics in medicinal chemistry, 14, 526-541
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Article • Self-assembled biotransesterified cyclodextrins as potential Artemisinin nanocarriers. II: In vitro behavior toward the immune system and in vivo biodistribution assessment of unloaded nanoparticles [Full paper ]
J. B.G. Yaméogo, A. Gèze, L. Choisnard, J-L Putaux, R. Mazet, C. Passirani, M. Keramidas, J-L Coll, N. Lautram, J. Bejaud, R. Semdé, D. Wouessidjewe
European Journal of pharmaceutics and biopharmaceutics, 88, 683-694
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Article • Topological defects in polycrystalline hexosomes from β-cyclodextrin fatty esters [Full paper ]
Putaux, J. L. Lancelon-Pin, C. Choisnard, L. Gèze, A. Wouessidjewe, D.
Soft Matter, 2022, 18, 2028-2038
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Article • Helical Inclusion Complexes of Amylose with Aromatic Compounds: Crystallographic Evidence for New V-type Allomorphs [Full paper ]
Le, C. A. K. Ogawa, Y. Grimaud, F. Nishiyama, Y. Morfin, I. Potocki-Veronese, G. Choisnard, L. Wouessidjewe, D. Putaux, J. L.
Crystal Growth & Design 2022
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Article • Pharmacokinetic study of intravenously administered artemisinin-loaded surface-decorated amphiphilic γ-cyclodextrin nanoparticles [Full paper ]
J. Boumbéwendin Gérard Yaméogo, R. Mazet, D. Wouessidjewe, L. Choisnard, D. Godin-Ribuot, J.-L. Putaux, R. Semdé, A. Gèze
Mat. Sci. Engin. C 2020, 106, 110281
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Article • Recent Advances in the Design of Topical Ophthalmic Delivery Systems in the Treatment of Ocular Surface Inflammation and Their Biopharmaceutical Evaluation
Mazet, R. Yameogo, J. B. G. Wouessidjewe, D. Choisnard, L. Geze, A.
Pharmaceutics, 2020, 12 (6), 570
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Article • Single Crystals of V-Amylose Complexed with Bicyclic Organic Compounds. Special Issue: Polymer‐Solvent Complexes and Intercalates [Full paper ]
Cong‐Anh‐Khanh Le Luc Choisnard Denis Wouessidjewe Jean‐Luc Putaux
MACROMOLECULAR SYMPOSIA
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Article • Polymorphism of crystalline complexes of V-amylose with fatty acids [Full paper ]
Cong-Anh-Khanh Le, Luc Choisnard, Denis Wouessidjewe, Jean-Luc Putaux
International Journal of Biological Macromolecules 2018,119, 555-564
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Article • Bioesterified polysubstituted-cycloedxtrin/surfactant nanoparticles obtained by multilevel self-assembly
L.Zerkoune, A. Angelova, L. Choisnard, A. Gèze, D. Wouessidjewe, S. Lesieur
ICOMF14 Proceedings, MATEC Web of conferences, 2013, 4, 05001
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Article • Monodisperse nanoparticles from self-assembling amphiphilic cyclodextrin: modulable tools for the encapsulation and controlled release of pharmaceuticals
A. Mendez-Ardoy, M. Gomez Garcia, A. Geze, J.-L. Putaux, D. Wouessidjewe, C. Ortiz Mellet, J. Defaye, J. M. Garcia Fernandez, J. M. Benito
Med. Chem. 2012, 8, 524-532.
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Article • Self-assembled biotransesterified cyclodextrins as artemisinin nanocarriers - I : Formulation, lyoavailability and in vitro antimalarial activity assessment
Josias B.G. Yameogo, c, Annabelle Geze, , Luc Choisnard, Jean-Luc Putaux, Adama Gansane, Sodiomon B. Sirimad, Rasmane Semde, Denis Wouessidjewe
Eur. J. Pharm. Biopharm, 2012, 80(3), 508-517.
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Article • Physicochemical Characterization of of a-, β-, and γ-Cyclodextrins Bioesterified with Decanoate Chains Used As Building Blocks of Colloidal Nanoparticles
L. Choisnard, A. Gèze, C. Vanhaverbeke, J. B. G. Yamogo, J.-L. Putaux, B. Brasme, L. Jullien, S. Boullanger, C. Elfakir, D. Wouessidjewe
Biomacromolecules, 2011, 12(8), 3031-3038.
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Article • Colloidal systems made of biotransesterified alpha, beta, and gamma cyclodextrins grafted with C10 alkyl chains
A. Geze, L. Choisnard, J-L. Putaux, D. Wouessidjewe
Materials science and engineering, 2009 ,C29,458-462
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Article • Characterisation of complex amphiphilic cyclodextrin mixtures by high-performance liquid chromatography and mass spectrometry.
F. Kieken, C. West, K. Keddadouche, C. Elfakir, L. Choisnard, A. Gèze, D. Wouessidjewe
J. Chrom. A, 2008, 1189, 385-391.
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Article • Poudres, granulés et comprimés dans Pharmacie Galénique : Formulation et technologie Pharmaceutique
V. Busignies, D. Chulia, L. Choisnard, R. de Challemaison, A. Geze, S. Stainmesse, J. Siepmann, P. Tchoreloff, M. Viana, P. Wehrlé, D. Wouessidjewe,
Editions Maloine 2007, Chapitre 2, 1-45.
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Article • Formes galéniques en développement dans Pharmacie Galénique : Formulation et technologie Pharmaceutique
S. Begu, A. Bochot, L. Choisnard, P. Couvreur, D. Duchene, F. Edwards, E. Fattal, A. Geze, G. Ponchel, V. Preat, C. Tourne-Petaeille, D. Wouessidjewe
Editions Maloine. 2007, Chapitre 8, 1-36.
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Article • Miscellaneous nanoaggregates made of beta-CD esters synthesised by an enzymatic pathway
L. Choisnard, A. Geze, B.G.J. Yaméogo, J-L. Putaux, D. Wouessidjewe
Int. J. Pharm. 2007, 344, 26-32.
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Article • Biodistribution of intravenously administered amphiphilic beta-cyclodxetrin nanospheres
A. Geze, L. Tieu Chau, L. Choisnard, J.-P. Mathieu, D. Marti-Batlle, L. Riou, J.-P. Putaux, D. Wouessidjewe
Int. J. Pharm. 2007, 344, 135-142.
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Book • Pharmacie Galénique : Formulation et technologie Pharmaceutique
poudres, granulés et comprimés dans Pharmacie Galénique
V. Busignies, D. Chulia, L. Choisnard, R. de Challemaison, A. Gèze, S. Stainmesse, J. Siepmann, P. Tchoreloff, M. Viana, P. Wehrlé, D. Wouessidjewe
2007 • 1-44, Maloine - Paris
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Book • Pharmacie Galenique : Formulation et technologie pharmaceutique
Formes galéniques en développement dans Pharmacie Galénique
S. Begu, A. Bochot, L. Choisnard, P. Couvreur, D. Duchene, F. Edwards, E. Fattal, A. Geze, G. Ponchel, V. Preat, C. Tourné-Peteilh, D. Wouessidjewe
2007 • 250-289, Maloine - Paris
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Article • Nanoparticles of b-cyclodextrin esters obtained by self-assembling of biotransesterified b-cyclodextrin
L. Choisnard, A. Geze, J.L. Putaux, Y.S. Wong, D. Wouessidjewe
Biomacromolecules 2006, 7, 515-520.
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Article • Experimental design optimization for screening relvant free phenolic acids from various preparations used in Burkina Faso folk medicine
M. Kienbrebego, L. Choisnard, C. E. Lamien, A. Meda, D. Wouessidjewe, O. Nacoulma
Afr. J. Trad. Comp. Alt. Med. 2006, 3, 115-128.
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Patent • Preparation of nanosphere amphiphilic cyclodextrin derivatives as biological transporters
J. Defaye, P. Balbuena, J.M. Benito, A. Diaz Moscoso, C. Di Giorgio, J.M. Garcia Fernandez, A. Geze, M. Gomez Garcia, C. Ortiz Mellet, P. Vierling, D. Wouessidjewe
2006 • CNRS
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Article • Differential effects of cyclodextrins and derivatives on the biological behavior of the myocardial perfusion imaging agent 99mTcN-NOET
L. Riou, C. Ghezzi, D. Wouessidjewe, H. Law, J.-P. Mathieu, J. Defaye, R. Bontron, R. Pasqualini, D. Fagret
Eur. J. Pharm. Biopharm. 2005, 61, 40-49.
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Article • Efficient size control of amphiphilic cyclodextrin nanoparticles through a statistical mixture design methodology.
L. Choisnard, A. Geze, M. Bigan, J. L. Putaux, D. Wouessidjewe
J. Pharm. Pharmaceut. Sci. 2005, 8, 593-600
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Article • Acute toxicity and antioxydant property of Striga hermonthica (Del) Benth (Scrophulariaceae)
M. Kiendrebeogo, M.-G. Dijoux-Franca,C-E. Lamien, A. Meda, D. Wouessidjewe, O.-G. Nacoulma.
African J. Biotechn. 2005, 4, 919-922.
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Article • Enhanced degradation of fluorene in soil slurry by Absidia cylindrospora and maltosyl-cyclodextrin
D. Garon, L. Sage, D. Wouessidjewe, F. Seigle-Murandi
Chemosphere 2004, 56, 159-166.
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Article • Long term stability study of amphiphilic b-cyclodextrin nanosphere suspensions monitored by dynamic light scattering and cryo-transmission electron microscopy
A. Gèze, J.-L. Putaux, L. Choisnard, P. Jéhan, D. Wouessidjewe
J. Microencapsul. 2004, 21, 607-613.
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Article • Stoichiometry and formation constants of six PAHs with gamma-cyclodextrin determined by high performance liquid chromatography using a cyano stationary phase
C. Ravelet, A. Ravel, C. Grosset, A. Villet, A. Geze, D. Wouessidjewe, E. Peyrin
J. Liq. Chromatogr. Relat. Technol. 2002, 25, 421-432
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Article • Chromatographic determination of the association constants between nimesulide and native and modified beta-cyclodextrins
C. Ravelet, A. Geze, A. Villet, C. Grosset, A. Ravel D. Wouessidjewe, E. Peyrin
J. Pharm. Biomed. Anal. 2002, 29, 425-429
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Article • Influence of chemical structure of amphiphilic b-cyclodextrins on their ability to form stable nanoparticles
A. Gèze, S. Aous, I. Baussanne, J.-L. Putaux, J. Defaye, D. Wouessidjewe
Int. J. Pharm. 2002, 242, 301-305.
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Article • Influence of surfactants on solubility and fungal degradation of fluorene
D. Garon, D. Krivobok, D. Wouessidjewe, F. Seigle-Murandi
Chemosphere 2002, 47,303-309.
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Article • Cyclodextrins in pharmaceutical nanoparticles (Revue)
D. Duchêne, G. Ponchel, D. Wouessidjewe, A. Bochot
Biolog. J. Armenia 2001, 53, 125-135.
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Patent • Multiparticulate pharmaceutical dosage form.
T. Beckert, L. Briand, G. Bergmann, M. Assmus, D. Wouessidjewe
2000 • Roëhm Pharma Polymers, groupe Degussa