Article

Projet
 
Yung-Sing WONG,   
Titre
Synthesis of an uncharged tetra-cyclopeptide acting as a transmembrane carrier: Enhanced cellular and nuclear uptake  
Auteurs
Francisco Hilario, Flaviane Traore, Mohamed Dit Mady Zwick, Vincent Berry, Laurence Simoes-Pires, Claudia A. Cuendet, Muriel Fantozzi, Nicolas Pereira de Freitas, Rossimiriam Maynadier, Marjorie Wein, Sharon Vial, Henri Wong, Yung-Sing
Edition
Org. Lett. 2017, 19, 612-615
Année
2017
Résumé
A small uncharged cyclopeptide scaffold inspired by a natural product and designed to undergo postfunctionalizations was used as a new transmembrane vector. A bioactive and fluorescent triazole aminocoumarin was bound to this carrier to facilitate its moving across cell and subcellular membranes, and this led to an increase in its cell toxicity