Jean-Luc DECOUT

Professeur au DPM depuis le 01-09-1998

Bureau : E304

rf.sepla-elbonerg-vinu@tuoceD.cuL-naeJ

Tel : 0476635317

Fax : 0476635299

 Equipe « COMET »

Projets

  • Drug design rationnel et cibles thérapeutiques complexes. Certaines cibles thérapeutiques sont complexes à modéliser, et nécessitent une expertise et des méthodes de calcul avancées. Leur étude requiert des associations innovantes entre chimie médicinale, RMN et calculs théoriques. L'objectif du projet est le développement de nouveaux inhibiteurs de métalloenzymes, d'interactions protéine-protéine, ou de multiples cibles, conçus de manière rationnelle.

Publications

  • Article • Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity [Full paper ]

    L. Froux, A. Elbahnsi, B. Boucherle, A. Billet, N. Baatallah, B. Hoffmann, J. Alliot, R. Zelli, W. Zeinyeh, R. Haudecoeur, A. Fortuné, S. Mirval, C. Simard, P. Lehn, J.-P. Mornon, I. Callebaut, J.-L. Décout

    Eur. J. Med. Chem. 2020, 190, 112116

  • Article • A One-Pot Synthesis of Highly Functionalized Purines [Full paper ]

    R. Zelli, W. Zeinyeh, R. Haudecoeur, J. Alliot, B. Boucherle, I. Callebaut, J.-L. Decout

    Org. Lett. 19, 2017, 23, 6360-6363

  • Article • A new straightforward synthesis of 2’, 3’-didehydro-2’, 3’-dideoxy-2’-(2”- (trimethylsilyl)ethylthio)thymidine, key intermediate for the synthesis of 2’-substituted thionucleosides 

    Maralise P. Oliveira, Lucas L. Franco, Maria C. A. Lima, Cláudia M. O. Simões, Suely L. Galdino, Ivan R. Pitta, Jean-Luc Décout, Ricardo J. Alves

    J. Braz. Chem. Soc. 26, 816-821, 2015

  • Article • New 7-methylguanine derivatives targeting the influenza PB2 cap-binding domain. [Full paper ]

    S. Pautus, P. Sehr, J. Lewis, A. Fortuné, A. Wolkerstorfer, O. Szolar, D. Guilligay, T. Lunardi, J.-L. Decout, S. Cusack.

    J. Med. Chem. 2013, 56, 8915-8930.

  • Article • Anti-retroviral and cytostatic activity of 2',3'-dideoxyribonucleotide 3'-disulfides. 

    B. Gerland, J. Desire, J. Balzarini, J.-L. Decout.

    Bioorg. Med. Chem. 2008, 16, 6824-6831.

  • Article • Direct preparation of nucleoside vinyl disulfides from 2-(trimethylsilyl)ethyl sulfides, an access to vinylthiols. 

    B. Gerland, J. Desire, M. Lepoivre, J.-L. Decout

    Org. Lett. 9, 2007, 3021-3023.

  • Patent • Process for the preparation of nucleoside disulfides and thiosulfinates 

    J.-L. Decout, B. Gerland, J. Desire

    2006 • Université de Grenoble I / CNRS

  • Patent • Preparation of thionucleosides as antiviral and antitumor agents 

    J.-L. Decout, B. Gerland, J. Desire, M. Lepoivre, J. Balzarini.

    2006 • Université de Grenoble I / CNRS

  • Article • Sugar-Modified Thionucleosides: Chemistry and Inhibition of Ribonucleotide Reductases and S-Adenosyl-L-Homocysteine Hydrolases. 

    J.-L. Decout, S. F. Wnuk

    Frontiers in Nucleosides and Nucleic Acids Ed. by RF Schinazi and DC Liotta, 2004 IHL Press

  • Book • Frontiers in Nucleosides and Nucleic Acids 

    Sugar-Modified Thionucleosides: Chemistry and Inhibition of Ribonucleotide Reductases and S-Adenosyl-L-Homocysteine Hydrolases.

    J.-L. Decout, S. F. Wnuk

    2004 • 235-266, IHL Press - Tucker (GA), USA

  • Article • Deoxyribonucleoside 2’- or 3’-mixed disulfides: prodrugs to target ribonucleotide reductase and/or to inhibit HIV reverse transcription 

    B. Roy, S. Chambert, M. Lepoivre, A.-M. Aubertin, J. Balzarini, J.-L. Decout

    J. Med. Chem. 2003, 46, 2565-2568

  • Article • Thionucleotides as inhibitors of ribonucleotide reductase 

    B. Roy, S. Chambert, M. Lepoivre, J.-L. Decout

    Nucleosides Nucleotides Nucleic Acids 2003, 22, 883-885.

  • Article • Recent developments in the synthesis, the chemical modifications and the biological applications of sulfur modified nucleosides, nucleotides and oligonucleotides. 

    S. Chambert, J.-L. Decout

    Org. Prep. Proc. Int. 2002, 34, 27-85.

  • Article • 2-Trimethylsilylethyl sulfides in the von Braun cyanogen bromide reaction : selective preparation of thiocyanates and application to nucleoside chemistry. 

    S. Chambert, F. Thomasson, J.-L. Decout

    J. Org. Chem. 2002, 67, 1898 - 1904.

  • Article • The 2-(trimethylsilyl)ethyl sulfur group in synthesis 

    S. Chambert, J. Desire, J.-L. Decout

    Synthesis 2002, 16, 2319-2334 (revue)

  • Article • Combining theoretical and experimental data to decipher CFTR 3D structures and functions 

    B. Hoffmann, A. Elbahnsi, P. Lehn, J.-L. Décout, F. Pietrucci, J.-P. Mornon, I. Callebaut

    Cell. Mol. Life Sci. 2018, in press.

  • Oral Comm • Une approche rationnelle pour la thérapie de la mucoviscidose 

    Benjamin Boucherle

  • Oral Comm • Discovery of novel tailored F508del-CFTR binder correctors based on 3D structure models of entire CFTR protein for treating Cystic Fibrosis 

    Clément Boinot, Mathilde Jollivet Souchet, Brice Hoffmann, Jean-Paul Mornon, Benjamin Boucherle, Antoine Fortuné, Jean-Luc Decout, Pierre Lehn, Isabelle Callebaut, Frédéric Becq

  • Oral Comm • Models of the 3D structure of CFTR: from the understanding of the protein functions to the design of correctors  

    Brice Hoffmann, Jean-Paul Mornon, Benjamin Boucherle, Antoine Fortuné, Romain Haudecoeur, Clément Boinot, Mathilde Jollivet, Jean-Luc Decout, Frédéric Becq, Pierre Lehn, Isabelle Callebaut

  • Article • A new 9-alkyladenine-cyclic methylglyoxal diadduct activates wt- and F508del-cystic fibrosis transmembrane conductance regulator (CFTR) in vitro and in vivo. 

    B. Boucherle, J. Bertrand, B. Maurin, B.-L. Renard, A. Fortuné, B. Tremblier, F. Becq, C. Norez, J.-L. Decout.

    Eur. J. Med. Chem. 2014, 83, 455-465.

  • Patent • Compounds for treating cystic fibrosis 

    Isabelle Callebaut, Jean-Paul Mornon, Jean-Luc Decout, Frédéric Becq, Pierre Lehn, Brice Hoffmann, Benjamin Boucherle, Romain Haudecoeur, Antoine Fortuné, Clément Boinot, Julien Alliot

    2014 • 

  • Article • In vivo study and validation of novel pharmacological modulators of water and ionic intestinal secretion for future therapeutic applications. 

    L. Dannhoffer, J.-L. Decout, F. Becq.

    Fund. Clin. Pharmacol. 2011, 25, 79.

  • Article • An expeditious access to 5-pyrimidinol derivatives from cyclic methylglyoxal diadducts, formation of argpyrimidines under physiological conditions and discovery of new CFTR inhibitors. 

    B.-L. Renard, B. Boucherle, B. Maurin, M.-C. Molina, C. Norez, F. Becq, J.-L. Decout.

    Eur. J. Med. Chem. 2011, 46, 1935-1941.

  • Article • Identification of a novel water soluble activator of wild-type and F508del CFTR: GPact-11a. 

    J. Bertrand, B. Boucherle, A. Billet, P. Melin-Heschel, L. Dannhoffer, C. Vandebrouck, C. Jayle, C. Routaboul, M.-C. Molina, J.-L. Decout, F. Becq, C. Norez.

    Eur. Respir. J. 2010, 36, 311-322.

  • Oral Comm • Pharmacological characterization of a novel water-soluble activator of F508del-CFTR 

    J. Bertrand, B. Boucherle, L. Dannhoffer, P. Melin, C. Routaboul, J. L. Décout, F. Becq, C. Norez

  • Oral Comm • Activation of chloride secretion in human airway epithelial cells by a new pyrrolo[2,3-b]pyrazine 

    L. Dannhoffer, P. Melin, C. Faveau, B. Boucherle, C. Jayle, P. Corbi, Y. Mettey, J. L. Décout, F. Becq

  • Article • Discovery of alpha-aminoazaheterocycle-methylglyoxal adducts as a new class of high affinity inhibitors of CFTR chloride channels. 

    C. Routaboul, C. Norez, P. Melin, M.-C. Molina, B. Boucherle, F. Bossard, S. Noel, R. Robert, C. Gauthier, F. Becq, J.-L. Decout.

    J. Pharmacol. Exp. Ther. 2007, 322, 1023-1035.

  • Patent • Zwitterionic CFTR channel modulators, preparation, pharmaceutical compositions and therapeutic use. 

    J.-L. Decout, C. Routaboul, F. Becq, C. Norez

    2003 • Université Grenoble I / CNRS / Université de Poitiers

  • Article • New stereoselective reaction of methylglyoxal with 2-aminopyridines and adenine derivatives : formation of imino acid-nucleic base derivatives in water under mild conditions. 

    C. Routaboul, L. Dumas, I. Gautier-Luneau, J. Vergne, M.-C. Maurel, J.-L. Decout

    Chem. Commun. 2002, 1114-1115.

  • Article • Effect of cardiolipin on the antimicrobial activity of a new amphiphilic aminoglycoside derivative on Pseudomonas aeruginosa 

    J. Swain, M. El Khoury, J. Kempf, F. Briée, P. Van Der Smissen, J.-L. Décout, M.-P. Mingeot-Leclercq

    PLoS One 2018, 13, e0201752

  • Article • Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines 

    L. Zimmermann, J. Kempf, F. Briée, J. Swain, M.-P. Mingeot-Leclercq, J.-L. Décout

    Eur. J. Med. Chem. 2018, in press.

  • Article • New broad-spectrum antibacterial amphiphilic aminoglycosides active against resistant bacteria: From neamine derivatives to smaller neosamine analogues. [Full paper ]

    L. Zimmermann, I. Das, J. Desire, G. Sautrey, V. Barros R. S., M. El Khoury, M.-P. Mingeot-Leclercq, J.-L. Decout

    J. Med. Chem. 2016, 59, 9350-9369

  • Article • New amphiphilic neamine derivatives active against resistant Pseudomonas aeruginosa and their interactions with lipopolysaccharides [Full paper ]

    Guillaume Sautrey, Louis Zimmermann, Magali Deleu, Alicia Delbar, Luiza Souza Machado, Katy Jeannot, Françoise Van Bambeke, Julien M. Buyck, Jean-Luc Decout, Marie-Paule Mingeot-Leclercq

    Antimicrob. Agents Chemother. 2014, 58, 4420-4430.

  • Article • Tuning the antibacterial activity of amphiphilic neamine derivatives and comparison to paromamine homologues. [Full paper ]

    L. Zimmermann, A. Bussiere, M. Ouberai, I. Baussanne, C. Jolivalt, M.-P. Mingeot-Leclercq, J.-L. Decout.

    J. Med. Chem. 2013, 56, 7691-7705.

  • Article • Antibiotic drugs aminoglycosides cleave DNA at abasic sites: Shedding new light on their toxicity? [Full paper ]

    M. Perigolo, J.-F. Constant, M. Peuchmaur, I. Pitta, J.-L. Decout.

    Chem. Res. Tox. 2013, 26, 1710–1719.

  • Article • Major increase of the reactivity and selectivity in aminoglycoside O-alkylation due to the presence of fluoride ions. 

    O. Jackowski, A. Bussière, C. Vanhaverbeke, I. Baussanne, E. Peyrin, M.-P. Mingeot-Leclercq, J.-L. Decout.

    Tetrahedron 2012, 68, 737-746.

  • Article • A Peptide Nucleic Acid-aminosugar conjugate targeting transactivation response element of HIV-1 RNA genome shows a high bioavailability in human cells and strongly inhibits tat-mediated transactivation of HIV-1. [Full paper ]

    I. Das, J. Desire, D. Manvar, I. Baussanne, V. N. Pandey, J.-L. Decout.

    J. Med. Chem. 2012, 55, 6021-6032.

  • Article • The Pseudomonas aeruginosa membranes: a target for a new amphiphilic aminoglycoside derivative? 

    M. Ouberai, F. El Garch, A. Bussiere, M. Riou, D. Alsteens, L. Lins, I. Baussanne, Y. F. Dufrene, R. Brasseur, J.-L. Decout, M.-P. Mingeot-Leclercq.

    BBA - Biomembranes 2011, 1808, 1716–1727.

  • Article • Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. 

    I. Baussanne, A. Bussiere, S. Halder, C. Ganem-Elbaz, M. Ouberai, M. Riou, J.-M. Paris, E. Ennifar, M.-P. Mingeot-Leclercq, J.-L. Decout.

    J. Med. Chem. 2010, 53, 119-127.

  • Patent • Derives de glucosamine et leur utilisation comme agents antibacteriens. Brevet français déposé le 9/11/2010 (Université de Grenoble/CNRS). 

    J.-L. Decout, I. Das, J. Desire, I. Baussanne, M.-P. Mingeot-Leclercq.

    2010 • Université Joseph Fourier/CNRS

  • Article • Synthesis and transfection properties of a series of lipidic neamine derivatives. 

    T. Le Gall, I. Baussanne, S. Halder, N. Carmoy, T. Montier, P. Lehn, J.-L. Decout.

    Bioconjugate Chem. 2009, 20, 2032-2046.

  • Article • Copper(II) complexes of lipophilic aminoglycoside derivatives for the amino acid enantiomeric separation by ligand-exchange liquid chromatography. 

    M. Zaher, I. Baussanne, C. Ravelet, S. Halder, M. Haroun, J. Fize, J.-L. Decout, E. Peyrin.

    J Chromatogr A. 2008, 1185, 291-295.

  • Article • Unusual addition of amines to C-2 of vinyl sulfone-modified-β-D-pent-2-enofuranosyl carbohydrates: synthesis of a new class of β-anomeric D-arabino-2,3-Dideoxy-2-aminofuranosides. 

    I. Das, C. G. Suresh, J.-L. Decout, T. Pathak.

    Carbohydrate Res. 2008, 343, 1287-1296.

  • Patent • Nouveaux dérivés de la néamine, méthode de préparation et propriétés antibiotiques. 

    J.-L. Decout, I. Baussanne, J. Desire, J.-M. Paris.

    2008 • Université Joseph Fourier/CNRS

  • Article • A structure-based approach for targeting the HIV-1 genomic RNA dimerization initiation site. 

    E. Ennifar, J.-C. Paillart, S. Bernacchi, P. Walter, P. Pale, J.-L. Decout, R. Marquet, P. Dumas.

    Biochimie 2007, 89, 1195-1203

  • Article • Mechanism of RNA cleavage catalyzed by sequence specific polyamide nucleic acid-neamine conjugate. 

    B. Chaubey, S. Tripathi, J. Desire, I. Baussanne, J.-L. Decout, V. Pandey.

    Oligonucleotides 2007, 17, 302-313.

  • Article • Neamine dimers targeting the HIV-1 TAR RNA. 

    E. Riguet, J. Désiré, O. Boden, V. Ludwig, M. Göbel, C. Bailly, J.-L.Decout

    Bioorg. Med. Chem. Lett. 2005, 15, 4651-4655.

  • Article • A route for preparing new neamine derivatives targeting HIV-1 TAR RNA. 

    E. Riguet, J. Desire, C. Bailly, J.-L. Decout

    Tetrahedron 2004, 60, 8053-8064.

  • Article • A peptide nucleic acid-neamine conjugate that targets and cleaves HIV-1 TAR RNA inhibits viral replication. 

    E. Riguet, S. Tripathi, B. Chaubey, J. Desire, V. N. Pandey, J.-L. Decout.

    J. Med. Chem. 2004, 47, 4806-4809.

  • Patent • PNA-neamine conjugates and methods for producing and using the same. 

    J.-L. Decout, V. N. Pandey, E. Riguet

    2003 • University of Medicine and Dentistry of New Jersey, Newark, USA / Université de Grenoble I / CNRS

  • Article • A short chemically modified dsRNA-binding PNA (dbPNA) inhibits influenza viral replication by targeting viral RNA panhandle structure [Full paper ]

    J. Kesy, K. M. Patil, S. R. Kumar, Z. Shu, H. Y. Yong, L. Zimmermann, A. A. Lerk Ong, D.-F. Kaixin Toh, M. S. Krishna, L. Yang, J.-L. Decout, D. Luo, M. Prabakaran, G. Chen, E. Kierzek

    Bioconjugate Chem. 2019, 30, 931–943

  • Article • Chiral ligand-exchange chromatography of amino acids using porous graphitic carbon coated with a dinaphthyl derivative of neamine. 

    M. Zaher, C. Ravelet, I. Baussanne, A. Ravel, C. Grosset, J.-L Decout, E. Peyrin.

    Anal. Bioanal. Chem. 2009, 393, 655-660.

  • Article • Enantioseparation by micellar electrokinetic chromatography using a ligand exchange-based chiral pseudostationary phase 

    M. Zaher, C. Ravelet, C. Vanhaverbeke, I. Baussanne, S. Perrier, J. Fize, J.-L. Decout, E. Peyrin

    Electrophoresis, 2009, 30, 2869-2873

  • Article • Covalently bonded DNA aptamer chiral stationary phase for the chromatographic resolution of adenosine. 

    J. Ruta, C. Ravelet, J. Désiré, J.-L. Décout, E. Peyrin.

    Anal. Bioanal. Chem. 2008, 390, 1051-1057.

  • Article • Competitive affinity capillary electrophoresis assay based on a hybrid pre-incubation/on-capillary mixing format using an enantioselective aptamer as affinity ligand. 

    J. Ruta, C. Ravelet, I. Baussanne, J. Fize, J.-L. Decout, E. Peyrin.

    J. Sep.Sci. 2008, 31, 2239-2243

  • Patent • Chiral selectors for separating enantiomers of a compound. 

    E. Peyrin, J.-L. Décout, C. Ravelet, I. Baussanne.

    2007 • Université de Grenoble I/CNRS

  • Article • Aptamer-based enantioselective competitive binding assay for the trace enantiomer detection. 

    J. Ruta, C. Ravelet, I. Baussanne, J.-L. Decout, E. Peyrin.

    Anal. Chem. 2007, 79, 4716-4719.

  • Article • Sequence-specific nucleic acid damage induced by “enzyme activable” peptide nucleic acid conjugates 

    P. Simon, J.-L. Decout, M. Fontecave

    Angew. Chem. Int. Ed. 2006,45, 6859-6861.

  • Article • DNA detection through signal amplification using NADH:Flavin Oxidoreductase and oligonucleotide-flavin conjugates as cofactors 

    P. Simon, C. Dueymes, M. Fontecave, J.-L. Decout

    Angew. Chem. Int. Ed. 2005, 44, 2764-2767.

  • Article • New flavin and deazaflavin oligonucleotide conjugates for the amperometric detection of DNA hybridization. 

    S. Cosnier, C. Gondran, C. Dueymes, P. Simon, M. Fontecave, J.-L. Decout

    Chem. Commun. 2004, 1624-1625.

  • Article • Adenine-aptamer complexes : a bipartite RNA site which binds the adenine nucleic base. 

    M. Meli, J. Vergne, J.-L. Decout, M.C. Maurel

    J. Biol. Chem. 2002, 277, 2104-2111.

  • Article • Fluorescent DNA microarrays using deazaflavin-oligonucleotide probes. 

    C. Dueymes, J.-L. Decout, P. Peltie, M. Fontecave

    Angew. Chem. Int. Ed. 2002, 41, 486-489

  • Article • RNA-acting antibiotics: in vitro selection of RNA aptamers for the design of new bioactive molecules less susceptible to bacterial resistances 

    M.-C. Maurel, B. Biard, C. Moulinier, D. Braz, J. Nugier, I. Chaumas, M. Reboud-Ravaux, J-L. Decout

    J. Pharm. Pharmacol. 2002, 67, 1898-1904 (revue)

  • Patent • Method and support for biological analysis using oligonucleotides comprising a marker capable of enzymatic activation. 

    J.-L. Decout, M. Fontecave, C. Dueymes

    2001 • CEA / Université de Grenoble I

  • Patent • Analysis of biological targets using a biochip comprising a fluorescent marker 

    M. Cuzin, P. Peltie, M Fontecave, J.-L. Decout, C. Dueymes

    2000 • CEA / Université de Grenoble I