Benjamin BOUCHERLE  

Projets

• Synthèse et extraction orientés vers la diversité et la complexité. La diversité et la complexité moléculaires sont des éléments cruciaux pour le développement de molécules innovantes à visée thérapeutique. À travers ce projet, de nouvelles approches sont proposées pour reproduire la complexité des molécules naturelles, générer de la diversité et de la complexité à partir de composés simples, et combiner des espaces chimiques différents par la modification synthétique d'extraits naturels in situ.

• Drug design rationnel et cibles thérapeutiques complexes. Certaines cibles thérapeutiques sont complexes à modéliser, et nécessitent une expertise et des méthodes de calcul avancées. Leur étude requiert des associations innovantes entre chimie médicinale, RMN et calculs théoriques. L'objectif du projet est le développement de nouveaux inhibiteurs de métalloenzymes, d'interactions protéine-protéine, ou de multiples cibles, conçus de manière rationnelle.

Publications

• Article • Aurones and derivatives as promising New Delhi metallo-β-lactamase (NDM-1) inhibitors [Full paper ]

  Jérémy Caburet, Federica Verdirosa, Matis Moretti, Brayan Roulier, Giorgia Simoncelli, Romain Haudecoeur, Somayeh Ghazi, Hélène Jamet, Jean-Denis Docquier, Benjamin Boucherle, Marine Peuchmaur

  Bioorganic & Medicinal Chemistry 2024 97, 117559

• Article • A fragment-based drug discovery strategy applied to the identification of NDM-1 β-lactamase inhibitors [Full paper ]

  Jérémy Caburet, Benjamin Boucherle, Sofiane Bourdillon, Giorgia Simoncelli, Federica Verdirosa, Jean-Denis Docquier, Yohann Moreau, Isabelle Krimm, Serge Crouzy, Marine Peuchmaur

  European Journal of Medicinal Chemistry 240 (2022) 114599

• Article • Exploring the Structure-Activity Relationship of Benzylidene-2,3-Dihydro-1H-Inden-1-One Compared to Benzofuran-3(2H)-One Derivatives as Inhibitors of Tau Amyloid Fibers [Full paper ]

  Emeline Boukherrouba, Camille Larosa, Kim-Anh Nguyen, Jérémy Caburet, Laurent Lunven, Hugues Bonnet, Antoine Fortuné, Ahcène Boumendjel, Benjamin Boucherle, Sabine Chierici, Marine Peuchmaur

  Eur. J. Med. Chem. 2022, 231, 114139

• Article • β-Carboline as a Privileged Scaffold for Multitarget Strategies in Alzheimer’s Disease Therapy [Full paper ]

  A. Beato, A. Gori, B. Boucherle, M. Peuchmaur, R. Haudecoeur

  J. Med. Chem. 2021, 64, 13921422

• Patent • Method for synthesizing diversely substituted purines 

  Jean-Luc Decout, Renaud Zelli, Wael Zeinyeh, Benjamin Boucherle, Romain Haudecoeur

  2021 • 

• Article • Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity [Full paper ]

  L. Froux, A. Elbahnsi, B. Boucherle, A. Billet, N. Baatallah, B. Hoffmann, J. Alliot, R. Zelli, W. Zeinyeh, R. Haudecoeur, A. Fortuné, S. Mirval, C. Simard, P. Lehn, J.-P. Mornon, I. Callebaut, J.-L. Décout

  Eur. J. Med. Chem. 2020, 190, 112116

• Patent • Compounds for treating cystic fibrosis 

  Isabelle Callebaut, Jean-paul Mornon, Jean-Luc Decout, Frederic Becq, Pierre Lehn, Brice Hoffman, Benjamin Boucherle, Romain Haudecoeur, Antoine Fortune, Clement Boinot, Julien Alliot

  2019 • 

• Article • Expanding Chemical Frontiers: Approaches for Generating Diverse and Bioactive Natural Product-Like Compounds Libraries from Extracts [Full paper ]

  Aurélien Beato, Romain Haudecoeur, Benjamin Boucherle and Marine Peuchmaur

  Chem. Eur. J. 2024, e202304166

• Article • Investigation of Chemical Composition and Biological Activities of Ajuga pyramidalis—Isolation of Iridoids and Phenylethanoid Glycosides [Full paper ]

  A. Gori, B. Boucherle, A. Rey, M. Rome, C. Barette, E. Soleilhac, C. Philouze, M.-O. Fauvarque, N. Fuzzati, M. Peuchmaur

  Metabolites 2023, 13, 128

• Article • Development of an Innovative Maceration Technique to Optimize Extraction and Phase Partition of Natural Products [Full paper ]

  A. Gori, B. Boucherle, A. Rey, M. Rome, N. Fuzzati, M. Peuchmaur

  Fitoterapia 2021, 148, 104798

• Article • Phytochemical and Biological Investigation of Helianthemum nummularium, a High-Altitude Growing Alpine Plant Overrepresented in Ungulates Diets [Full paper ]

  M Agostini, I Hininger-Favier‡, L Marcourt‡, B Boucherle‡, B Gao, B M Hybertson, S K Bose, J M McCord, A Millery, M Rome, E Ferreira Queiroz, J-L Wolfender , C Gallet, A Boumendjel

  Planta Medica, 2020, 86, 1185-1190

• Article • A One-Pot Synthesis of Highly Functionalized Purines [Full paper ]

  R. Zelli, W. Zeinyeh, R. Haudecoeur, J. Alliot, B. Boucherle, I. Callebaut, J.-L. Decout

  Org. Lett. 19, 2017, 23, 6360-6363

• Article • Traditional uses, phytochemistry and pharmacological properties of African Nauclea species: A review [Full paper ]

  R. Haudecoeur, M. Peuchmaur, B. Pérès, M. Rome, G. Sotoing Taiwe, A. Boumendjel, B. Boucherle

  Journal of Ethnopharmacology, 2018, 212, 106-136

• Article • Occurrences, biosynthesis and properties of aurones as high-end evolutionary products. [Full paper ]

  B. Boucherle, M. Peuchmaur, A. Boumendjel, R. Haudecoeur.

  Phytochemistry, 2017, 142, 92-111.

• Article • Nauclea latifolia: biological activities and alkaloid phyto-chemistry of a West African tree 

  B. Boucherle, R. Haudecoeur, E. Ferreira Queiroz, M. De Waard, J.-L. Wolfender, R. J. Robins, A. Boumendjel

  Nat. Prod. Rep. 2016, 33, 1034-1043

• Oral Comm • Une approche rationnelle pour la thérapie de la mucoviscidose 

  Benjamin Boucherle

• Oral Comm • Discovery of novel tailored F508del-CFTR binder correctors based on 3D structure models of entire CFTR protein for treating Cystic Fibrosis 

  Clément Boinot, Mathilde Jollivet Souchet, Brice Hoffmann, Jean-Paul Mornon, Benjamin Boucherle, Antoine Fortuné, Jean-Luc Decout, Pierre Lehn, Isabelle Callebaut, Frédéric Becq

• Oral Comm • Models of the 3D structure of CFTR: from the understanding of the protein functions to the design of correctors  

  Brice Hoffmann, Jean-Paul Mornon, Benjamin Boucherle, Antoine Fortuné, Romain Haudecoeur, Clément Boinot, Mathilde Jollivet, Jean-Luc Decout, Frédéric Becq, Pierre Lehn, Isabelle Callebaut

• Article • A new 9-alkyladenine-cyclic methylglyoxal diadduct activates wt- and F508del-cystic fibrosis transmembrane conductance regulator (CFTR) in vitro and in vivo. 

  B. Boucherle, J. Bertrand, B. Maurin, B.-L. Renard, A. Fortuné, B. Tremblier, F. Becq, C. Norez, J.-L. Decout.

  Eur. J. Med. Chem. 2014, 83, 455-465.

• Patent • Compounds for treating cystic fibrosis 

  Isabelle Callebaut, Jean-Paul Mornon, Jean-Luc Decout, Frédéric Becq, Pierre Lehn, Brice Hoffmann, Benjamin Boucherle, Romain Haudecoeur, Antoine Fortuné, Clément Boinot, Julien Alliot

  2014 • 

• Article • An expeditious access to 5-pyrimidinol derivatives from cyclic methylglyoxal diadducts, formation of argpyrimidines under physiological conditions and discovery of new CFTR inhibitors. 

  B.-L. Renard, B. Boucherle, B. Maurin, M.-C. Molina, C. Norez, F. Becq, J.-L. Decout.

  Eur. J. Med. Chem. 2011, 46, 1935-1941.

• Article • Identification of a novel water soluble activator of wild-type and F508del CFTR: GPact-11a. 

  J. Bertrand, B. Boucherle, A. Billet, P. Melin-Heschel, L. Dannhoffer, C. Vandebrouck, C. Jayle, C. Routaboul, M.-C. Molina, J.-L. Decout, F. Becq, C. Norez.

  Eur. Respir. J. 2010, 36, 311-322.

• Oral Comm • Pharmacological characterization of a novel water-soluble activator of F508del-CFTR 

  J. Bertrand, B. Boucherle, L. Dannhoffer, P. Melin, C. Routaboul, J. L. Décout, F. Becq, C. Norez

• Oral Comm • Activation of chloride secretion in human airway epithelial cells by a new pyrrolo[2,3-b]pyrazine 

  L. Dannhoffer, P. Melin, C. Faveau, B. Boucherle, C. Jayle, P. Corbi, Y. Mettey, J. L. Décout, F. Becq

• Article • Discovery of alpha-aminoazaheterocycle-methylglyoxal adducts as a new class of high affinity inhibitors of CFTR chloride channels. 

  C. Routaboul, C. Norez, P. Melin, M.-C. Molina, B. Boucherle, F. Bossard, S. Noel, R. Robert, C. Gauthier, F. Becq, J.-L. Decout.

  J. Pharmacol. Exp. Ther. 2007, 322, 1023-1035.

• Thesis • La mucoviscidose : traitements actuels et perspectives thérapeutiques 

  Benjamin Boucherle, Norman Bideau

  2005 • 

• Article • Arylthiosemicarbazones as antileishmanial agents [Full paper ]

  J. I. Manzano, F. Cochet, B. Boucherle, V. Gómez-Pérez, A. Boumendjel, F. Gamarro, M. Peuchmaur

  Eur. J. Med. Chem. 2016, 123, 161-170.

• Article • Could we expect new praziquantel derivatives? A meta pharmacometrics/pharmacoinformatics analysis of all antischistosomal praziquantel derivatives found in the literature [Full paper ]

  V.B. Ribeiro da Silva, B. Boucherle, J. El-Methni, B. Hoffmann, A.L. da Silva, A. Fortune, M. do Carmo Alves de Lima, A. Thomas

  SAR AND QSAR IN ENVIRONMENTAL RESEARCH 2019, VOL. 30, NO. 6, 383–401

• Article • Identification of PDZ ligands by docking-based virtual screening for the development of novel analgesic agents  [Full paper ]

  Naoual Bouzidi, Hemantkumar Deokar, Alexandre Vogrig, Benjamin Boucherle, Isabelle Ripoche, Isabelle Abrunhosa-Thomas, Liam Dorr, Anne-Sophie Wattiez, Lu-Yun Lian, Philippe Marin, Christine Courteix, Sylvie Ducki

  Bioorganic & medicinal chemistry letters 03/2013; 23(9)

• Article • Structure-Based Design of PDZ Ligands as Inhibitors of 5-HT2A Receptor/PSD-95 PDZ1 Domain Interaction Possessing Anti-hyperalgesic Activity [Full paper ]

  Alexandre Vogrig, Liam Dorr, Naoual Bouzidi, Benjamin Boucherle, Anne-Sophie Wattiez, Elisabeth Cassier, Gary Vallon, Isabelle Ripoche, Isabelle Abrunhosa-Thomas, Philippe Marin, Lionel Nauton, Vincent Thery, Christine Courteix, Lu-Yun Lian, Sylvie Ducki

  ACS Chemical Biology 07/2013; 8(10), 2209 − 2216

• Article • Synthesis and evaluation of bidentate ligands designed to interact with PDZ domains [Full paper ]

  Benjamin Boucherle, Alexandre Vogrig, Hemantkumar Deokar, Naoual Bouzidi, Isabelle Ripoche, Isabelle Thomas, Philippe Marin, Sylvie Ducki

  Bioorganic & medicinal chemistry 05/2011; 19(14):4346-54

• Article • NMR evaluation of interactions between substituted-indole and PDZ1 domain of PSD-95 [Full paper ]

  Alexandre Vogrig, Benjamin Boucherle, Hemantkumar Deokar, Isabelle Thomas, Isabelle Ripoche, Lu-Yun Lian, Sylvie Ducki

  Bioorganic & medicinal chemistry letters 06/2011; 21(11):3349-53

• Thesis • Synthèse et évaluation de modulateurs de la protéine CFTR. 

  Benjamin Boucherle

  2008 • Université Joseph Fourier