Marine PEUCHMAUR

Parcours et intérêts

2015 : Habilitation à diriger des recherches
2008-2009 : Post-doctorat Trinity College - Dublin - Irlande
2007-2008 : Post-doctorat IBMM - Montpellier
2004-2007 : Doctorat en Chimie - Département de Pharmacochimie Moléculaire - UJF Grenoble
2004 : Ingénieur chimiste - ENSCM Montpellier
2004 : DEA Chimie des Biomolécules : Synthèse, Structure et Réactivité - U. Montpellier 2

Projets

• Drug design rationnel et cibles thérapeutiques complexes. Certaines cibles thérapeutiques sont complexes à modéliser, et nécessitent une expertise et des méthodes de calcul avancées. Leur étude requiert des associations innovantes entre chimie médicinale, RMN et calculs théoriques. L'objectif du projet est le développement de nouveaux inhibiteurs de métalloenzymes, d'interactions protéine-protéine, ou de multiples cibles, conçus de manière rationnelle.

• Synthèse et extraction orientés vers la diversité et la complexité. La diversité et la complexité moléculaires sont des éléments cruciaux pour le développement de molécules innovantes à visée thérapeutique. À travers ce projet, de nouvelles approches sont proposées pour reproduire la complexité des molécules naturelles, générer de la diversité et de la complexité à partir de composés simples, et combiner des espaces chimiques différents par la modification synthétique d'extraits naturels in situ.

Publications

• Article • Epstein-Barr Virus Encephalitis: A Review of Case Reports from the Last 25 Years [Full paper ]

  M. Peuchmaur, J. Voisin, M. Vaillant, A. Truffot, J. Lupo, P. Morand, M. Le Maréchal, R. Germi

  Microorganisms 2023, 11, 12, 2825

• Article • Aurones and derivatives as promising New Delhi metallo-β-lactamase (NDM-1) inhibitors [Full paper ]

  Jérémy Caburet, Federica Verdirosa, Matis Moretti, Brayan Roulier, Giorgia Simoncelli, Romain Haudecoeur, Somayeh Ghazi, Hélène Jamet, Jean-Denis Docquier, Benjamin Boucherle, Marine Peuchmaur

  Bioorganic & Medicinal Chemistry 2024 97, 117559

• Article • A fragment-based drug discovery strategy applied to the identification of NDM-1 β-lactamase inhibitors [Full paper ]

  Jérémy Caburet, Benjamin Boucherle, Sofiane Bourdillon, Giorgia Simoncelli, Federica Verdirosa, Jean-Denis Docquier, Yohann Moreau, Isabelle Krimm, Serge Crouzy, Marine Peuchmaur

  European Journal of Medicinal Chemistry 240 (2022) 114599

• Article • Exploring the Structure-Activity Relationship of Benzylidene-2,3-Dihydro-1H-Inden-1-One Compared to Benzofuran-3(2H)-One Derivatives as Inhibitors of Tau Amyloid Fibers [Full paper ]

  Emeline Boukherrouba, Camille Larosa, Kim-Anh Nguyen, Jérémy Caburet, Laurent Lunven, Hugues Bonnet, Antoine Fortuné, Ahcène Boumendjel, Benjamin Boucherle, Sabine Chierici, Marine Peuchmaur

  Eur. J. Med. Chem. 2022, 231, 114139

• Article • β-Carboline as a Privileged Scaffold for Multitarget Strategies in Alzheimer’s Disease Therapy [Full paper ]

  A. Beato, A. Gori, B. Boucherle, M. Peuchmaur, R. Haudecoeur

  J. Med. Chem. 2021, 64, 13921422

• Article • Expanding Chemical Frontiers: Approaches for Generating Diverse and Bioactive Natural Product-Like Compounds Libraries from Extracts [Full paper ]

  Aurélien Beato, Romain Haudecoeur, Benjamin Boucherle and Marine Peuchmaur

  Chem. Eur. J. 2024, e202304166

• Article • Investigation of Chemical Composition and Biological Activities of Ajuga pyramidalis—Isolation of Iridoids and Phenylethanoid Glycosides [Full paper ]

  A. Gori, B. Boucherle, A. Rey, M. Rome, C. Barette, E. Soleilhac, C. Philouze, M.-O. Fauvarque, N. Fuzzati, M. Peuchmaur

  Metabolites 2023, 13, 128

• Article • Development of an Innovative Maceration Technique to Optimize Extraction and Phase Partition of Natural Products [Full paper ]

  A. Gori, B. Boucherle, A. Rey, M. Rome, N. Fuzzati, M. Peuchmaur

  Fitoterapia 2021, 148, 104798

• Article • Glycosyl-Substituted Dicarboxylates as Detergents for the Extraction, Overstabilization, and Crystallization of Membrane Proteins [Full paper ]

  K.-A. Nguyen, M. Peuchmaur, S. Magnard, R. Haudecoeur, C. Boyère, S. Mounien, I. Benammar, V. Zampieri, S. Igonet, V. Chaptal, A. Jawhari, A. Boumendjel, P. Falson

  Angew. Chem. Int. Ed. Engl. 2018, 57, 2948-2952.

• Patent • Clamps moléculaires d’extraction et stabilisation en solution des protéines membranaires. 

  K. A. Nguyen, S. Magnard, M. Peuchmaur, J. Dauvergne, A. Boumendjel, P. Falson

  2017 • 

• Article • Traditional uses, phytochemistry and pharmacological properties of African Nauclea species: A review [Full paper ]

  R. Haudecoeur, M. Peuchmaur, B. Pérès, M. Rome, G. Sotoing Taiwe, A. Boumendjel, B. Boucherle

  Journal of Ethnopharmacology, 2018, 212, 106-136

• Article • Occurrences, biosynthesis and properties of aurones as high-end evolutionary products. [Full paper ]

  B. Boucherle, M. Peuchmaur, A. Boumendjel, R. Haudecoeur.

  Phytochemistry, 2017, 142, 92-111.

• Article • Chemical composition of the pods of Albizia polyphylla [Full paper ]

  Rajemiarimoelisoa C. F., Boyère C., Pellissier L., Peuchmaur M., Randrianarivo H. R., Doll Rakoto D. A., Jeannoda V. L., Boumendjel A.

  Nat. Prod. Res. 2016, 30, 1557-1560.

• Article • New Pseudodimeric Aurones as Palm Pocket Inhibitors of Hepatitis C Virus RNA-dependent RNA Polymerase [Full paper ]

  Amel Meguellati, Abdelhakim Ahmed-Belkacem, Alessandra Nurisso, Wei Yi, Rozenn Brillet, Nawel Berqouch, Laura Chavoutier, Antoine Fortuné, Jean-Michel Pawlotsky, Ahcène Boumendjel, Marine Peuchmaur

  Eur. J. Med. Chem. 2016, 115, 217-229

• Article • Arylthiosemicarbazones as antileishmanial agents [Full paper ]

  J. I. Manzano, F. Cochet, B. Boucherle, V. Gómez-Pérez, A. Boumendjel, F. Gamarro, M. Peuchmaur

  Eur. J. Med. Chem. 2016, 123, 161-170.

• Article • Antibiotic drugs aminoglycosides cleave DNA at abasic sites: Shedding new light on their toxicity? [Full paper ]

  M. Perigolo, J.-F. Constant, M. Peuchmaur, I. Pitta, J.-L. Decout.

  Chem. Res. Tox. 2013, 26, 1710–1719.

• Article • 2-Indolylmethylenebenzofuranones as first effective inhibitors of ABCC2 [Full paper ]

  E. Baiceanu, K.-A. Nguyen, L. Gonzalez-Lobato, F. Loghin, M. Le Borgne, A. Boumendjel, M. Peuchmaur, P. Falson

  Eur. J. Med. Chem, 2016, 122, 408-418

• Article • Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter [Full paper ]

  V. Chaptal, V. Zampieri, Benjamin Wiseman, C. Orelle, Juliette Martin, K.A. Nguyen, A. Gobet, M. Di Cesare, S. Magnard, W. Javed, Jad, Eid, A. Kilburg, M. Peuchmaur, J. Marcoux, M. Monticelli, M. Hogbom, G. Schoehn, J.M. Jault, A.Boumendjel et al

  Sci. Adv., 2022, 8, eabg9215

• Article • Ovarian cancer cells cisplatin sensitization agents selected by mass cytometry target ABCC2 inhibition [Full paper ]

  E. Comsa, K.-A. Nguyen, F. Loghin, A. Boumendjel, M. Peuchmaur, T. Andrieu, P. Falson.

  Future Med. Chem. 2018, 10, 11, 1349-1360

• Article • Piperidinyl-Embeded Chalcones Possessing anti PI3Kδ Inhibitory Properties Exhibit Anti-atopic Properties in Preclinical Models 

  C. Dumontet, G.Beck, F. Gardebien, R. Haudecoeur, D. Mathé, E.-L. Matera, A. Tourette, E. Mattei, J. Esmenjaud, C. Boyere, A. Nurisso, M. Peuchmaur, B. Peres, G. Bouchaud, A. Magnan, G. Monneret and A. Boumendjeld

  Eur. J. Med. Chem. 2018, In Press

• Article • Disruption of fibres from the AcPHF6 tau model by naturally occurring aurones and synthetic analogs 

  L. Lunven, H. Bonnet, S. Yahiaoui, L. Da Costa, M. Peuchmaur, A. Boumendjel, S. Chierici

  ACS Chem. Neurosci. 2016, 7, 995-1003.

• Article • B-ring modified aurones as promising allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase. 

  A. Meguelatti, A. Ahmed-Belkacem, W. Yi, R. Haudecoeur, M. Crouillère, R. Brillet, J.-M. Pawlotsky, A. Boumendjel, M. Peuchmaur

  Eur. J. Med. Chem. 2014, 80, 579-592.

• Article • Structure-Activity Relationships in the Development of Allosteric Hepatitis C Virus RNA-Dependent RNA Polymerase Inhibitors: Ten Years of Research [Full paper ]

  R. Haudecoeur, M. Peuchmaur, A. Ahmed-Belkacem, J.-M. Pawlotsky,A. Boumendjel

  Med. Res. Rev. 2013, 33, 934-984.

• Article • Flexible synthesis and evaluation of diverse anti-Apicomplexa cyclic peptides. 

  Traore M., Mietton F., Maubon D., Peuchmaur M., Fancisco Hilario F., Pereira de Freitas R., Bougdour A., Curt A., Maynadier M., Vial H., Pelloux H., Hakimi M.-A., Wong, Y.-S.

  J. Org. Chem. 2013, 78, 3655-3675

• Article • Further characterization of a putative serine protease contributing to the γ-secretase cleavage of β-amyloid precursor protein. 

  Peuchmaur M., Lacour M.-A., Sevalle J., Lisowski V., Touati-Jallabe Y., Rodier F., Martinez J., Checler F., Hernandez J.-F.

  Bioorg. Med. Chem. 2013, 21, 1018-1029.

• Article • A Straightforward conversion of Aurones to 2-Benzoylbenzofuranes: Transformation of One Class of Natural Products into Another 

  S. Yahiaoui, M. Peuchmaur, A. Boumendjel

  Tetrahedron, 2011, 67, 7703-7707

• Article • Hypervalent iodine(III)-mediated tandem oxidative reactions: application for the synthesis of bioactive polyspirocyclohexa-2,5-dienones. 

  M. Traoré, S. Ahmed-Ali, M. Peuchmaur, Y.-S. Wong.

  Tetrahedron 2010, 66, 5863-5872.

• Article • Solid-phase synthesis of isocoumarins: a traceless halocyclization approach. 

  Peuchmaur M., Lisowski V., Gandreuil C., Maillard L. T., Martinez J., Hernandez J.-F.

  J. Org. Chem. 2009, 74, 4158-4165.

• Article • Expanding the chemical space: Diversity-Oriented Synthesis. 

  M. Peuchmaur, Y.-S. Wong.

  Comb. Chem. High Throughput Screen. 2008, 11, 587-601.

• Article • Enhanced antimalarial activity of novel synthetic aculeatin derivatives. 

  M. Peuchmaur, N. Saïdani, C. Botte, E. Marechal, H. Vial, Y.-S. Wong.

  J. Med. Chem. 2008, 51, 4870-4873.

• Article • Diastereodivergent Strategies for the Synthesis of Homochiral Aculeatins. 

  M. Peuchmaur, Y.-S. Wong.

  J. Org. Chem. 2007, 72, 5374-5379.

• Patent • Nouveaux composes polyspiranniques, leur application dans le traitement du paludisme ou de la toxoplasmose et leur procede de preparation. 

  M. Peuchmaur, Y.-S. Wong, N. Saidani, C. Botte, H. Vial, E. Marechal.

  2007 • Universite Grenoble I, CNRS.

• Thesis • Synthèse de composés polyspiranniques par oxydation phenolique. Synthèse totale des aculéatines et d'analogues antipaludiques 

  M. Peuchmaur

  2007 • Université Joseph Fourier

• Article • Studies towards the synthesis of aculeatin C. 

  M. Peuchmaur, Y.-S. Wong.

  Synlett 2007, 18, 2902-2906.

• Patent • Pyrazine derivatives and electronic devices using them 

  Schaefer, Thomas; Peuchmaur, Marine; Rogers, Jonathan; Craig, Michael Robert

  2005 • Ciba Specialty Chemicals Holding Inc., Switz.