Article

Projet
 
Ahcène BOUMENDJEL, Basile PERES, Romain HAUDECOEUR, Florine LECERF-SCHMIDT,   
Titre
Biomimetic Synthesis of Tramadol  
[Full paper ]
Auteurs
F. Lecerf-Schmidt, R. Haudecoeur, B. Peres, M. M. Ferreira Queiroz, L. Marcourt, S. Challal, E. Ferreira Queiroz, G. Sotoing Taiwe, T. Lomberget, M. Le Borgne, J.-L. Wolfender, M. De Waard, R. J. Robins and A. Boumendjel
Edition
Chem. Commun. 2015, 15, 14451-14453.
Année
2015
Résumé
In 2013, we reported that the root bark extract of Nauclea latifolia Sm. (Rubiaceae) collected in a biosphere reserve in the north of Cameroun contains large quantities (0.4% w/w) of (±)-(1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxy-phenyl)- Tramadol has recently been isolated from the roots and bark of Nauclea latifolia. A plausible biosynthetic pathway has been proposed and the product-precursor relationship probed by 13C position-specific isotope analysis. Further exploring this pathway, we demonstrate that a key step of the proposed pathway can be achieved in mild conditions that mimic in vivo catalysis.